Michael Gbinije scored 22 points, Malachi Richardson 17 and four Syracuse players scored in double figures as the Orange rode a dominating second half to defeat visiting Florida State 85-72 on Thursday night.
Tyler Lydon chipped in with 15 and Trevor Cooney 10 for the Orange (17-8, 7-5 ACC), which won its fourth straight and seventh in their past eight.
Devon Bookert led FSU (16-8, 6-6) with 15 points. Malik Beasley had 14 and Dwayne Bacon 11.
Syracuse outscored Florida State 43-27 in the second half on the strength of 71-percent shooting. The Orange hit 15 of 21 from the field, including going 3-of-6 from 3-point range.
The Seminoles went just 9-of-26 from the field in the second half and 2-of-10 from 3-point range.
For the game, Syracuse hit 62 percent from the field and 8 of 17 from beyond the arc.
Before Thursday night's game, the Seminoles had won six of their past eight games after starting the season 0-3.
This was considered an important week for Florida State as it tries to get to the NCAA Tournament for the first time since 2012. The Seminoles next host No. 12 Miami on Sunday.
Coach Leonard Hamilton insisted before Thursday's game that his team wasn't looking ahead.
"We have a lot more work to do. ... Nobody in this league gets into the NCAA Tournament winning six games in their conference," Hamilton said.
"If we start worrying about what's going to happen in March, we won't take care of what's happening in February."