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Luminescent work wins Nobel

Brain cells from a mouse glow with colorful fluorescent proteins at Harvard University. Scientists tagged the cells with some 90 colors.

Harvard University via Associated Press

Brain cells from a mouse glow with colorful fluorescent proteins at Harvard University. Scientists tagged the cells with some 90 colors.

Three U.S.-based scientists won a Nobel Prize on Wednesday for turning a glowing green protein from jellyfish into a revolutionary way to watch the tiniest details of life within cells and living creatures.

Osamu Shimomura, a Japanese citizen who works in the United States, and Americans Martin Chalfie and Roger Tsien shared the chemistry prize for discovering and developing green fluorescent protein, or GFP.

When exposed to ultraviolet light, the protein glows green. It can act as a marker on otherwise invisible proteins within cells to trace them as they go about their business. It can tag individual cells in tissue. And it can show when and where particular genes turn on and off.

Researchers worldwide now use GFP to track development of brain cells, the growth of tumors and the spread of cancer cells. It has let them study nerve cell damage from Alzheimer's disease and see how insulin-producing beta cells arise in the pancreas of a growing embryo, for example.

In awarding the prize, the Royal Swedish Academy compared the impact of GFP on science to the invention of the microscope. For the past decade, the academy said, the protein has been "a guiding star" for scientists.

GFP's chemical cousins produce other colors, which let scientists follow multiple cells or proteins simultaneously.

"This is a technology that has literally transformed medical research," said Dr. John Frangioni, an associate professor of medicine and radiology at Harvard Medical School.

Last year, in what the Nobel citation called a "spectacular experiment," Harvard researchers announced that they had tagged brain cells in mice with some 90 colors.

GFP was first discovered by Shimomura at Princeton University in 1961.

Some 30 years later, Chalfie showed that the GFP gene could make individual nerve cells in a tiny worm glow bright green.

Tsien's work provided GFP-like proteins that extended the scientific palette to a variety of colors.

The trio will split the $1.4-million award.

"My accomplishment was just the discovery of a protein," said Osamu Shimomura, 80, who now works at the Marine Biological Laboratory in Woods Hole, Mass., and the Boston University Medical School.

"It's not something out of the blue, but you never know when it's going to come or if it's going to come, so it's always a big surprise," said Martin Chalfie, 61, a professor at Columbia University in New York who said he slept through the Nobel committee's phone calls early Wednesday because he'd accidentally adjusted his telephone to ring very softly.

Roger Tsien, 56, a professor at the University of California at San Diego and an investigator with the Howard Hughes Medical Institute, thanked scientists worldwide and said that when they do "good things with GFP and its progeny," he can "bask in the warmth of that glow."

Luminescent work wins Nobel 10/08/08 [Last modified: Wednesday, November 3, 2010 3:13pm]
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