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Vaccine helps shrink tumors from melanoma

ORLANDO — For the first time, a novel treatment that trains the immune system to fight cancer has shown modest benefit in late-stage testing against the deadly skin cancer melanoma.

The approach is called a cancer vaccine, even though it treats disease rather than prevents it. In a study of about 180 patients already getting standard therapy, the vaccine doubled the number of patients whose tumors shrank, and extended the time until their cancer worsened by about six weeks.

"Although the differences may seem small, we need to understand that in many cancers, our progress has been built in small incremental changes over time," said Dr. Len Lichtenfeld of the American Cancer Society.

Trends in the study suggest that the vaccine also may improve survival, but patients need to be followed longer to see if this proves true, said Dr. Douglas Schwartzentruber, cancer chief at Goshen Health System in central Indiana. He led the study and gave results Saturday at an American Society of Clinical Oncology meeting.

The National Cancer Institute developed the vaccine, which has not yet been commercially licensed. The institute sponsored the study, along with Novartis AG, which makes interleukin-2, the standard treatment.

Interleukin-2 stimulates the immune system to make specialized cells that attack cancer. However, only 10 percent to 15 percent of patients with advanced melanoma see their tumors shrink with this harsh treatment, which causes severe flulike symptoms and must be given in the hospital.

The vaccine contains a substance found on the surface of many skin cancer cells. The idea is to help the immune system recognize this as a threat and provoke it to attack.

In the study, people were given the vaccine or a dummy shot a day before starting intravenous interleukin-2 treatment. This was repeated about four to six times every three weeks.

About 22 percent of patients given the vaccine plus interleukin-2 saw their tumors shrink by half or more, compared with 10 percent of those getting interleukin-2 alone. Vaccine users saw their cancer stabilize for three months, compared with half that time for the others.

Researchers will tweak the vaccine more to try to improve the number of people who benefit, said Dr. Patrick Hwu, melanoma chief at the University of Texas M.D. Anderson Cancer Center in Houston.

It now can only be given to people with a certain tissue type — about half of those with melanoma.

Melanoma is the most serious form of skin cancer. Last year in the United States, there were about 62,480 new cases and 8,420 deaths from the disease.

Vaccine helps shrink tumors from melanoma 05/30/09 [Last modified: Monday, November 7, 2011 5:25pm]
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