Make us your home page

Today’s top headlines delivered to you daily.

(View our Privacy Policy)

New guidelines on Parkinson's disease emphasize treating underlying symptoms

Dr. Theresa Zesiewicz uses a feeding tube to give dinner to her mother, Frances, who has Parkinson’s disease. Zesiewicz is the lead author of new national guidelines on treating the nonmotor symptoms of Parkinson’s disease.


Dr. Theresa Zesiewicz uses a feeding tube to give dinner to her mother, Frances, who has Parkinson’s disease. Zesiewicz is the lead author of new national guidelines on treating the nonmotor symptoms of Parkinson’s disease.


Once the tremors begin, so do the rumors. Celebrities like Muhammad Ali, Michael J. Fox and Janet Reno have highlighted the shaking, loss of motor control and coordination that are hallmarks of Parkinson's disease.

But for many patients, it's the symptoms that receive far less attention — like sleep disorders, depression, sexual dysfunction and severe constipation — that can make the disease even worse.

After undergoing deep brain stimulation a year ago to treat the motor symptoms of the disease, Bill Mader, 65, no longer needs a wheelchair to get around. But the Hudson resident, who goes by "Duke," continues to struggle with insomnia, constipation and rapid changes in his blood pressure that leave him fatigued.

"It's small things that have been so hard," he said. "The side symptoms, unfortunately, make the Parkinson's much worse."

At least, Mader says, he has found an understanding neurologist in Dr. Theresa Zesiewicz, medical director of the Parkinson's Disease Clinic at the University of South Florida's main campus.

She is also the lead author of a new set of national guidelines on treating the nonmotor symptoms of Parkinson's disease. Zesiewicz has gained a firsthand understanding of their impact while caring for her 85-year-old mother, who is in the end stages of the disease.

"These are symptoms that are very under-recognized and under-treated in terms of Parkinson's disease," she said.

In Parkinson's disease, certain nerve cells in the brain waste away, resulting in the loss of muscle coordination and other issues. The condition, which can affect both men and women, usually sets in after age 60.

In her mother, Zesiewicz witnessed how much quality of life can deteriorate for the 90 percent of Parkinson's patients who experience sleep disorders.

She saw her mother lose her sense of smell and taste, symptoms that often precede the tremors, and suffer through a range of gastrointestinal problems associated with Parkinson's disease.

"You see 20 patients a day, then you come home and you live with it," Zesiewicz said. "It's different when you see what it means to live in a bed and take liquid food because of the swallowing issues."

Zesiewicz is grateful that her mother is not among the 50 percent of Parkinson's patients who suffer from depression, which may result from neurological changes as well as the difficulty of living with the disease. Depression also can be a precursor to the classic symptoms of the disease.

Many patients are embarrassed to talk to their doctors about issues like sexual dysfunction and extreme constipation, which can result in painful bloating and loss of appetite.

So Zesiewicz, working with a committee of the American Academy of Neurology, reviewed the scientific literature on treatment options for such symptoms in patients with Parkinson's to produce standards for diagnosing and treating these problems.

The guidelines, published this week in the medical journal Neurology, identified medications found to have helped relieve constipation, excessive daytime sleepiness and erectile dysfunction in Parkinson's patients.

But not enough is known about treating loss of bladder control, insomnia and anxiety in Parkinson's patients. "We are woefully behind in the research studies on a lot of these nonmotor symptoms," Zesiewicz said.

While more research funding is needed, Zesiewicz said neurologists treating patients with Parkinson's disease also must better coordinate with other specialists, including urologists and doctors specializing in gastrointestinal disorders.

Letitia Stein can be reached at or (813) 226-3322. For more health news, visit

New guidelines on Parkinson's disease emphasize treating underlying symptoms 03/17/10 [Last modified: Wednesday, March 17, 2010 4:48pm]
Photo reprints | Article reprints

© 2017 Tampa Bay Times


Join the discussion: Click to view comments, add yours

  1. Nearly 1 in 4 Tampa Bay homeowners considered equity rich

    Real Estate

    If your home is worth at least 50 percent more than you owe, you're rich — equity rich that is.

    About one in four Tampa Bay homeowners are considered "equity rich." [Associated Press file photo]
  2. Trump strategist Steve Bannon: No military solution in North Korea


    BRIDGEWATER, N.J. — President Donald Trump's chief strategist Steve Bannon says there's no military solution to the threat posed by North Korea and its nuclear ambitions, despite the president's recent pledge to answer further aggression with "fire and fury."

    Steve Bannon, chief White House strategist to President Donald Trump, has drawn fire from some of Trump's closest advisers. [Associated Press]
  3. Rays have their chances, but end up with another loss (w/video)

    The Heater

    TORONTO — The litany of games the Rays have given away this season is long enough, arguably too long. So the only way to get to the postseason is make up for some of those losses by grabbing some wins when the opportunity is presented, especially at this time of year when the margin is diminished and the stakes …

    Associated Press
  4. Dunedin man accused of possessing child pornography


    DUNEDIN — A 57-year-old man was arrested Wednesday, accused of intentionally downloading child pornography, the Pinellas County Sheriff's Office said.

    Richard Beal Anger, 57, of Dunedin faces 11 counts of possession of child pornography. [Courtesy of the Pinellas County Sheriff's Office]
  5. Pence cuts short Latin America trip and pressures Chile to sever all ties to North Korea


    SANTIAGO, Chile — Vice President Mike Pence is cutting short his Latin America trip by one day to return to Washington for a strategy meeting Friday at Camp David with President Donald Trump and the national security team.

    Vice President Mike Pence urged Chilean President Michelle Bachelet to take a tougher stand against North Korea on Wednesday in Santiago, Chile.