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Polycystic ovary syndrome is leading cause of infertility in women

Carrie English, left, learned she was pregnant with her son Aidan, now 3, within three months of starting treatment for polycystic ovary syndrome.

MELISSA LYTTLE | Times

Carrie English, left, learned she was pregnant with her son Aidan, now 3, within three months of starting treatment for polycystic ovary syndrome.

PINELLAS PARK — Carrie English had her first child when she was 19, with no trouble.

Then a constellation of annoying problems cropped up.

"I had been having a lot of symptoms, which I didn't realize were symptoms," says English, now 31. "The biggest thing is I wasn't getting a period at all for about a year-and-a-half or two years."

During her mid 20s, English developed a bad case of acne, gained about 50 pounds and noticed that the hair on her face was becoming dark.

When she tried to get pregnant again and couldn't, she finally went to the doctor and learned she had polycystic ovary syndrome, or PCOS, the No. 1 cause of infertility in American women.

PCOS is a hormone disorder in which, for reasons not fully understood, the ovaries make too much androgen hormone, the male sex hormones women normally produce in tiny amounts. The excess androgen interferes with ovulation, causing infertility, along with acne, excess facial hair and male pattern hair loss.

Patients may stop having menstrual periods or have months with no periods followed by bouts of heavy bleeding.

Many women with PCOS also develop problems with insulin, causing a condition known as insulin resistance. By age 40, as many as 40 percent of PCOS patients have diabetes.

"The condition is really misnamed, because it's a metabolic disorder, a hormone disorder," says Dr. Jennifer Hayes, a St. Anthony's Hospital gynecologist and the physician who treated English for PCOS. The condition got its name from the small benign cysts that form on a patient's ovaries, but, Hayes says, it's the mixed-up signals sent to the brain and the resulting hormonal imbalance that cause problems.

Because the body has trouble using insulin, most women with PCOS have a weight problem.

"PCOS puts the body into a weight-gaining mode," Hayes says. "Their brain is telling them to eat sugar, so they crave carbs. It makes for crazy mood swings, accelerated weight gain and difficult weight loss."

PCOS affects up to one in 15 American teens and women, but can be so mild that patients don't seek treatment.

Early diagnosis and treatment are important because PCOS puts women at high risk for serious complications including diabetes, high blood pressure, heart disease and stroke.

Treatment depends on a patient's goals, but most doctors immediately put patients on an exercise program and a low-carbohydrate, heart-healthy diet to promote weight loss. They may also prescribe birth control medication to bring menstrual cycles under control and to reduce acne, facial hair growth and hair loss.

But, if infertility is the chief complaint, as it was for Carrie English, patients may be offered the diabetes medication metformin, which helps control blood sugar and androgen hormone levels, and can also help trigger ovulation. If that alone doesn't work, other fertility medication may be added.

English was prepared to wait the year or two that her doctor said it could take to normalize her hormones and achieve pregnancy. But, within three months of starting metformin, she was delighted to learn she was pregnant.

"I took three home pregnancy tests, because I thought it was wrong," she recalls.

There's no cure for PCOS, so patients must always keep symptoms in check. But English says her infertility issues are over.

After the birth of her second child, son Aidan in 2006, she says, "We're done."

Irene Maher can be reached at imaher@sptimes.com or (813) 226-3416.

Polycystic ovary syndrome is leading cause of infertility in women 12/23/09 [Last modified: Wednesday, December 30, 2009 2:51pm]

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