Sunday, February 25, 2018
Health

Zika's structure has been revealed, bringing scientists closer to a vaccine

Zika, the mosquito-borne virus linked to miscarriage and severe microcephaly in the fetuses of infected women, just lost a little bit of its edge to researchers. On Thursday, a Purdue University team published the virus's structure for the first time in the journal Science.

By outlining the physical structure of the virus in near-atomic detail, they have made it possible for scientists to determine the unique properties that make Zika so dangerous — and how those abilities might be knocked out with vaccines and treatments.

Zika is a flavivirus — a member of the same family as other mosquito-borne illnesses, such as dengue, West Nile and yellow fever — and its strong similarity with those better-understood viruses was confirmed in the study. But scientists are most interested in what makes Zika different.

In an interview with the Washington Post, Purdue's Michael Rossmann, who co-led the team with Richard Kuhn, said their examinations with an electron microscope had found significant changes to the Zika virus' surface.

It shares a basic structure with all flaviviruses: Genetic info in the form of RNA is surrounded by a fatty membrane, then encased in a protein shell with a 20-sided face. The protein shells are made of 180 copies of two different proteins, each composed of chains of different amino acids. Once inside a target cell, the virus breaks apart and forces the host to do its bidding, replacing the instructions coded into the cell's DNA with those programmed by viral RNA.

Zika differs most from other flaviviruses at a spot thought to be crucial to the cellular break-in. At this site, a carbohydrate molecule — made of different sugars — sits on the virus's protein shell. The so-called glycosylation site where Zika differs actually protrudes from the shell of the virus. In other viruses, similar protrusions act like strangers offering candy, tricking the human cell into binding with the invader. Like other flaviviruses, Zika seems to have a unique smattering of amino acids around that area.

"That makes it very different in a very important respect," Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told the Post. While the findings don't begin to explain how or why these changes might allow Zika to have such disastrous effects on fetal brain development, he said, "it provides a very plausible explanation for why we're seeing Zika do things these other flaviviruses don't do."

Comments
Mental illness dominating post-Parkland gun debate, but at what cost?

Mental illness dominating post-Parkland gun debate, but at what cost?

A familiar and polarizing tug of war over gun control and access to guns has re-emerged in the week since the massacre at Marjory Stoneman Douglas High School in Parkland, thrusting mental illness once again into the national conversation about mass ...
Published: 02/24/18
After Parkland, admissions to mental health treatment centers in Florida spike

After Parkland, admissions to mental health treatment centers in Florida spike

The emotional welfare of children follows predicatable patterns. In the fall, when school begins, beds at psychiatric treatment centers fill up. They empty again during summer break and the winter holidays.In recent years, doctors and psychologists h...
Published: 02/24/18
Doctors ordered a urine test after her surgery. That’ll be $17,850, the lab said

Doctors ordered a urine test after her surgery. That’ll be $17,850, the lab said

This is the debut of a monthly feature from Kaiser Health News and NPR that will dissect and explain real medical bills in order to shed light on U.S. health care prices and to help patients learn how to be more active in managing costs. Do you have ...
Published: 02/21/18
Updated: 02/22/18
Preventive treatment for peanut allergies succeeds in study

Preventive treatment for peanut allergies succeeds in study

The first treatment to help prevent serious allergic reactions to peanuts may be on the way. A company said Tuesday that its daily capsules of peanut flour helped sensitize children to nuts in a major study. Millions of children have peanut allergies...
Published: 02/20/18
Doctors were wrong when they told her immunotherapy wouldn’t cure her cancer

Doctors were wrong when they told her immunotherapy wouldn’t cure her cancer

No one expected the four young women to live much longer. They had an extremely rare, aggressive and fatal form of ovarian cancer. There was no standard treatment.The women, strangers to one another living in different countries, asked their doctors ...
Published: 02/20/18

Hernando Bloodmobile for Feb. 23

Bloodmobile locationsLifeSouth Community Blood Center will have blood drives at the following off-site locations during the coming week:Feb. 23: 10 a.m. to 3 p.m., Walmart, 13300 Cortez Blvd., Spring Hill; 10:30 a.m. to 5:30 p.m., Dickey’s Barbecue P...
Published: 02/20/18
Be prepared to help save a life: Learn CPR

Be prepared to help save a life: Learn CPR

70 percent of cardiac arrests outside hospitals happen at home. American Heart Association 3 a.m. Jan. 4, 2016. Lisa Peters of St. Petersburg is awakened by her husband, Rick, making strange gasping sounds. She can’t wake him. He feels cold. Only 46...
Published: 02/16/18

Step by step, ramp up your daily activity

Jae Bermanhe Washington Post There are many reasons that people avoid exercise. Time is an obvious one. Our lives are already busy — who has time to work out? Money is another common excuse. Gym memberships and equipment can get pricey.People often w...
Published: 02/16/18
Put Alaskan king crab leg shells to work in a creamy, dreamy bisque

Put Alaskan king crab leg shells to work in a creamy, dreamy bisque

Nothing says indulgence like noshing on some seriously giant Alaskan king crab legs. They’re not just tasty, they’re a low-fat source of protein: One leg has about 25 grams of protein and a host of vitamins and minerals (including sodium, incidentall...
Published: 02/15/18
Avocado toast gets a persimmon twist

Avocado toast gets a persimmon twist

You’ve likely seen persimmon in the grocery store and then shied away from it, not quite sure what to do with it. The most common variety in the United States is the fuyu persimmon, also called Japanese persimmon, and it looks similar to a slightly f...
Published: 02/15/18