CHICAGO — Jay Cutler and Brandon Marshall were too much to handle.
So was Tim Jennings.
Cutler threw two touchdowns to Marshall, and Jennings had two of the Bears' three interceptions of Eli Manning in a 27-21 victory over the winless Giants on Thursday.
Chicago snapped a two-game slide that followed a 3-0 start.
New York, which won the Super Bowl two seasons ago, is 0-6 for the first time since starting 0-9 in 1976. In addition, it has lost eight consecutive road games.
Manning threw interceptions on the Giants' first two possessions. Jennings returned the second 48 yards for a touchdown to help Chicago lead 24-14 at halftime.
The Giants cut it to 27-21 on Brandon Jacobs' 1-yard run late in the third. It came one play after Jennings was called for pass interference near the goal line.
But Jennings made up for it when he picked off Manning's overthrown pass intended for tight end Brandon Myers at the Bears 12 with 1:54 left to seal the victory.
The Giants had driven from their 11 to the 35, converting a third and 7 with an 11-yard catch by Hakeem Nicks.
Manning now has thrown a league-high 15 interceptions, which matches his total for all of last season.
Cutler was 24-of-36 for 262 yards after throwing for 358 against New Orleans on Sunday. Marshall played a huge role in this one after venting over a lack of catches against the Saints, finishing with nine receptions for 87 yards.
Bills won't rule out trading top safety
ORCHARD PARK, N.Y. — Bills general manager Doug Whaley said while he is not actively shopping star safety Jairus Byrd, he would listen to offers.
"We are not actively on the phone hammering out trying to look for a trade," he said. "By the same token, (team president) Russ Brandon would listen if someone wanted to trade."
Byrd, who has 18 interceptions over his five-year career, is set to make his season debut Sunday. Designated a franchise player, he missed the entire offseason hoping for a long-term contract before accepting the one-year tender Aug. 21. He then missed the first five games with plantar fasciitis in both feet.
More Bills: The NFL gave the team an extra day to sell enough tickets to avoid a blackout. The team must sell about 5,300 by today to avoid the league's first of the season.
Chargers: Starting left tackle King Dunlap, who sat out Sunday with a concussion, was cleared to practice. Running back Ryan Mathews has not been cleared after sustaining a concussion Sunday.
Colts: The team will honor quarterback Peyton Manning, whom it released in March 2012, when the Broncos visit Oct. 20. Details have not been finalized.
Cowboys: Receiver Miles Austin, who has missed two games with a sore hamstring, is expected to return Sunday.
Falcons: Receiver Brian Robiskie, son of the team's receivers coach, Terry Robiskie, signed. Robiskie, whom the Lions did not re-sign after 2012, has 43 catches for 485 yards and four touchdowns for three teams over four seasons.
Jets: Top cornerback Antonio Cromartie hurt his knee on a noncontact play during practice, and espn.com reported he had an MRI exam late Thursday. His status for Sunday hasn't been determined. Also quarterback David Garrard, who left the team in May because of a knee injury, re-signed. The team was granted a two-week roster exemption for him.
Lions: All-Pro receiver Calvin Johnson, who sat out Sunday with a knee injury, returned to practice. He will be a game-time decision.
Patriots: Starting defensive tackle Tommy Kelly missed practice with a right knee injury sustained last week against the Bengals. His status for Sunday hasn't been determined.
Steelers: Safety Will Allen, released by the Cowboys this week, signed.
Texans: Receiver Andre Johnson missed most of practice with a sore hamstring and will be a game-time decision.
Vikings: Matt Cassel will make his second straight start at quarterback despite Christian Ponder having recovered from a broken rib, espn.com reported. The team previously said ex-Buc Josh Freeman, signed Sunday, would not be ready to start. Also, star running back Adrian Peterson missed practice for personal reasons. But he is expected to back today and play Sunday.