ANAHEIM, Calif. — J.D. Drew hit a two-run homer in the ninth off Francisco Rodriguez as the Red Sox beat the Angels 7-5 on Friday to take a 2-0 lead in the best-of-five American League Division Series.
David Ortiz led off the inning with a double. After Kevin Youkilis grounded out, Drew sent a shot over the wall in right-center.
Boston will try to complete the sweep Sunday, when the series shifts to Fenway Park.
The defending World Series champion was ahead 4-0 after just 22 pitches by Ervin Santana — who had not faced Boston during the regular season.
Ortiz singled with two outs in the first to extend his division-series hitting streak to 13 games. Youkilis followed with a single, and Drew drove in Ortiz with a double.
Then Jason Bay, obtained from Pittsburgh in the three-team deal that sent Manny Ramirez from Boston to the Dodgers, drove a 2-and-2 pitch to centerfield for his second homer of the series. He also hit a two-run shot off John Lackey on in Boston's 4-1 victory in the opener Wednesday.
Boston's Daisuke Matsuzaka threw 108 pitches in five innings, allowing three runs and eight hits.
On six occasions during the regular season, the right-hander finished with 100 or more pitches while working five innings or fewer. He was 4-0 with a 3.60 ERA in those games.
Matsuzaka reached the century mark in the fifth before recording an out. He walked Mark Teixeira and Vladimir Guerrero before giving up Torii Hunter's second run-scoring single of the game, cutting Boston's lead to 5-3. But Dice-K retired the next three batters, including pinch-hitter Kendry Morales on a popup for the third out.
Matsuzaka gave up three consecutive singles with two outs in the first, including Hunter's run-scoring hit up the middle. But shortstop Alex Cora — starting in pace of rookie Jed Lowrie because manager Terry Francona preferred the matchup of Cora against Santana — made a nice play deep in the hole on a grounder by Juan Rivera and threw him out to end the inning.
Teixeira and Guerrero singled with two outs in the third, but Matsuzaka escaped the jam with the help of a questionable call by first-base umpire Kerwin Danley. Cora charged Hunter's grounder and threw him out in a close play. Hunter, first-base coach Alfredo Griffin and manager Mike Scioscia argued to no avail.
Boston added another run in the fourth on a run-scoring double by Jacoby Ellsbury, who was 3-for-5 with a run-scoring double and two stolen bases in Game 1. The Angels closed to 5-2 in the bottom half on a run-scoring single by Chone Figgins, but Dice-K struck out Garret Anderson with runners at the corners.
Matsuzaka was 9-0 with a 2.37 ERA in 13 road starts this season. The only time he faced the Angels this season was a 7-5 loss July 28 at Fenway Park, when he gave up a three-run homer to Hunter and a two-run shot by the since-traded Casey Kotchman.
Santana allowed five runs and eight hits in 51/3 innings. The right-hander departed with two men on base after Hunter — a seven-time Gold Glove center fielder — dropped Mark Kotsay's line drive for an error and Jason Varitek singled him to second.
Jose Arredondo came in and walked Cora before striking out Ellsbury and retiring Dustin Pedroia on a groundout.