SOUTH BEND, Ind. — Suddenly the only noise in an arena that had been loud all day was the happy screaming of the West Virginia Mountaineers, who had just managed possibly the biggest upset for the women's program.
West Virginia matched No. 2 Notre Dame's physical play and won most of the hustle points in a 65-63 victory that ended the Irish's 21-game winning streak.
Brooke Hampton hit two free throws with 4.6 seconds left to give the Mountaineers the lead. The celebration was on after Natalie Novosel's 15-footer bounced off the rim at the buzzer.
"This is a great win for us," West Virginia coach Mike Carey said. "We were below .500 three or four years ago and we beat Louisville at Louisville when they were ranked third in the country. This is right up there."
The Mountaineers (18-6, 8-3 Big East) went in on a three-game winning streak. Center Asya Bussie, who had 22 points and eight rebounds, said they were confident heading in.
"I just think we were more focused," said Bussie, who hit a turnaround jumper with 39 seconds left that tied the score at 63. "We prepared all week, and we just came in and did what we had to do to get the win."
Skyler Diggins scored a career-high 32 for Notre Dame (24-2, 11-1), which went in leading the nation at 83.2 points per game.
Diggins missed a contested layup that could have tied the score with less than 10 seconds to play. She fouled Hampton at midcourt as she went for a steal with 4.6 seconds to go.
NO. 5 DUKE 67, FSU 57: Haley Peters scored 18 to lead a balanced attack for the visiting Blue Devils (21-3, 12-0 ACC), who are bearing down on a third straight conference title. The Seminoles (13-13, 5-7) appear likely to miss the NCAA Tournament for the first time in seven years.
NO. 6 Miami 76, NO. 8 MD. 74: Stefanie Yderstrom scored a career-high 26 and Shenise Johnson added 20 for the visiting Hurricanes (22-3, 11-1 ACC), who won their 11th straight. The Terrapins (21-4, 8-4) led 66-60 with six minutes left before Johnson keyed a rally.
NO. 24 S.C. 62, UF 58: Markeshia Grant had 20 points and hit five 3-pointers, and LaKeisha Sutton scored on a left-handed scoop shot in the final minute as the host Gamecocks (19-6, 8-4 SEC) held off a rally by the Gators (16-9, 6-6).
NO. 4 STANFORD 82, UCLA 59: Nnemkadi Ogwumike had 25 points and eight rebounds for the host Cardinal (22-1, 13-0 Pac-12), which won its 19th straight.
NO. 10 OHIO ST. 80, NO. 16 PURDUE 71: Samantha Prahalis hit a 3-pointer from the right wing with 41 seconds left, helping the host Buckeyes (22-3, 9-3 Big Ten) rally past the Boilermakers (19-6, 9-3) and create a four-way tie atop the conference.
NO. 12 DEL. 94, GEORGIA ST. 56: Division I scoring leader Elena Delle Donne had 31 points in 25 minutes, and the visiting Blue Hens (21-1, 12-0 Colonial) won their 12th straight.
ST. JOHN'S 61, NO. 17 RUTGERS 52: Coach Kim Barnes Arico earned her school-record 169th win for the visiting Red Storm, which handed the Scarlet Knights (17-7, 6-5 Big East) their fourth straight loss.
NO. 18 PENN ST. 77, N'WESTERN 63: Alex Bentley scored 18 to lead four players in double figures, and the visiting Lions (20-5, 11-2 Big Ten) won their fourth straight.
NO. 21 GEORGIA 76, VANDY 63: Anne Marie Armstrong scored a career-high 23 for the host Bulldogs (19-6, 8-4 SEC), who led the entire game.
NO. 22 GA. TECH 56, NO. 22 UNC 54: Sasha Goodlett had 13 points for the visiting Yellow Jackets (18-7, 8-4 ACC), who handed the Tar Heels (17-8, 7-5) their third straight loss in the first women's game between teams with the same ranking since Jan. 14, 2003, when No. 14 Mississippi State beat No. 14 Vanderbilt 78-75.
NO. 12 G'TOWN 71, ST. JOHN'S 61: Freshman forward Greg Whittington scored a career-high 12, and the host Hoyas (19-5, 9-4) shot 61 percent in the second half and hit several clutch 3-pointers.
NO. 22 MICHIGAN 70, ILL. 61: Tim Hardaway scored 15 and Evan Smotrycz 13, and the Wolverines (19-7, 9-4 Big Ten) improved to 14-0 at home.