INDIANAPOLIS — San Diego's defense gave Peyton Manning another night to forget.
The Chargers picked off Manning four times, returning two for scores, in a 36-14 win Sunday that handed Indianapolis its most lopsided home loss since the four-time MVP has been the team's starting quarterback. The last time the Colts lost by this much at home was 31-3 to Seattle on Sept. 14, 1997.
San Diego won its fourth straight and stayed a game behind Kansas City in the AFC West.
"It's dedication to the system and tremendous on everyone's part," Chargers running back Mike Tolbert said of San Diego's playoff push.
Manning has seven interceptions the past two games — the most of any two-week span in his 13 seasons. Pro Bowl receiver Reggie Wayne walked off after getting hurt with 2:45 left.
The result ended the Colts' league record run of seven straight 12-win seasons.
Linebacker Kevin Burnett returned Manning's first pick 29 yards for a score. Safety Eric Weddle matched that with a 41-yard return in the third.
"San Diego did a good job," Manning said. "Offensively, we didn't do a real good job. I didn't do a real good job."