49ers (1-2) at Rams (1-2)
When/where: 8:25; Edward Jones Dome, St. Louis
TV/radio: NFL Network; 1010-AM, 98.7-FM
Line/OU: 49ers by 3; 42
San Francisco has dropped two straight by 20 or more points. And the Rams gave them trouble last season, being one of two teams to beat them over the final 10 regular-season games and tying them in the other meeting. San Francisco QB Colin Kaepernick already has more interceptions this season (four) than in his 13 games last season (three). His counterpart, Sam Bradford, has six touchdowns — as many as he had after six games last season. The 49ers are without LB Aldon Smith, who reportedly is receiving treatment for alcohol abuse. But they still might have the best linebacker corps in the NFL with Patrick Willis and NaVorro Bowman.
Greg Auman's pick: 49ers 27, Rams 17
49ers — Questionable: CB Nnamdi Asomugha (knee), OT Anthony Davis (shoulder), TE Vernon Davis (hamstring), S Raymond Ventrone (concussion), WR Kyle Williams (rib, knee), LB Patrick Willis (groin). Probable: LB Navorro Bowman (wrist), C Jonathan Goodwin (elbow), RB Frank Gore (knee), G Mike Iupati (shoulder), DT Ray McDonald (ankle), CB Carlos Rogers (knee), DT Justin Smith (shoulder).
Rams — Out: DE William Hayes (knee), T Rodger Saffold (knee). Probable: T Joe Barksdale (undisclosed), WR Chris Givens (knee), LB James Laurinaitis (foot), T Jake Long (foot), S T.J. McDonald (knee), TE Mike McNeill (chest), RB Daryl Richardson (foot), G Chris Williams (foot).