Jaguars (0-5) at Broncos (5-0)
4 p.m. Ch. 10 Broncos by 26½, 53½
Yes, you can watch Peyton Manning and friends try to cover a huge spread. You might have read Denver averages 46 points while Jacksonville has totaled 51. The Jags got a boost from WR Justin Blackmon, who had a long TD and 136 yards fresh off a four-game ban. Denver has four players — WR Demaryius Thomas, WR Eric Decker WR Wes Welker and TE Julius Thomas (above) — with more receiving yards than Bucs leader Vincent Jackson (292). So yes, it will cover.
The pick: Broncos 48, Jaguars 13
Titans (3-2) at Seahawks (4-1)
4 p.m. Seahawks by 13, 40½
Tennessee is averaging exactly as many yards (321.2) as it is allowing. Seattle seeks to rebound from its first loss. New name I like to carefully pronounce: Tennessee DT Ropati Pitoitua, who has as many sacks (five) in five games as he did in his first four seasons. Speaking of names, I'm suggesting "ATV" as a nickname for Titans CB Alterraun Verner (above), who has four picks and an NFL-best 11 passes defensed. Warning to Titans QB Ryan Fitzpatrick: Seattle is tied for first with 15 takeaways.
The pick: Seahawks 34, Titans 21
Saints (5-0) at Patriots (4-1)
4:25 p.m. Ch. 13 Patriots by 1½, 50½
A battle of elite QBs. The Saints and Drew Brees won the last meeting, in 2009, but Tom Brady (above) and the Patriots are 3-1 in the series. Brady has Bucs castoff LeGarrette Blount leading the club in rushing and an undrafted rookie, Kenbrell Thompkins, with a team-high three TD catches. Saints TE Jimmy Graham continues a torrid pace at 593 yards and six TDs. Despite his years in the NFC South, Pats and former Bucs CB Aqib Talib seeks his first interception vs. the Saints.
The pick: Saints 28, Patriots 21
Cardinals (3-2) at 49ers (3-2)
4:25 p.m. 49ers by 10½, 41
49ers WR Anquan Boldin (above) had five 1,000-yard seasons among seven in Arizona before a trade to Baltimore in 2010. He's on pace to get back over 1,000 for the first time since. San Francisco has won seven of eight in the series, but QB Colin Kaepernick could use a third target. Boldin and TE Vernon Davis account for 617 yards with no one else even at 100. Turnovers are always key, but both teams are even in turnover margin. Watch Cards WR Michael Floyd, who had 166 yards and a touchdown in the last meeting.
The pick: 49ers 28, Cardinals 17
Redskins (1-3) at Cowboys (2-3)
8:30 p.m. Ch. 8 Cowboys by 5, 53½
The Cowboys are tied for the NFC East lead, even after a 51-48 loss to the Broncos. Tony Romo (above) was brilliant, throwing for 506 yards and five touchdowns before a costly late interception. Watch out for rookie Terrence Williams, who had 151 yards receiving, including an 82-yard TD. The Redskins' Alfred Morris needs the ball more. He's averaging 5.3 yards per carry, better than any running back ahead of him in yards. He averaged 156 against Dallas in 2012 with four touchdowns.
The pick: Redskins 24, Cowboys 21
Colts (4-1) at Chargers (2-3)
8:40 p.m. Monday ESPN. Colts by 1½, 50
Andrew Luck (above) as the next John Elway? After last week, Luck has nine winning drives in the fourth quarter and overtime, the most of any quarterback in his first 21 games. San Diego's Philip Rivers has 13 touchdown passes as well as 400-plus yards in three of his past four games. Chargers RB Danny Woodhead has more catches (31) than carries (28) with three touchdown catches. Colts RB Trent Richardson went for 122 and a touchdown against the Chargers in 2012 while with Cleveland.
The pick: Chargers 35, Colts 24
Packers (2-2) at Ravens (3-2)
1 p.m. Packers by 3, 48½
Take away the records, and it's a huge game. Baltimore has dominated at home, 35-7 under coach John Harbaugh and winners of 13 straight against NFC teams. Ravens LB Terrell Suggs, who had three sacks last week against Miami, can set the franchise record by getting one in his sixth straight game. Green Bay needs a consistent running game. Rookie Eddie Lacy (above) had 99 yards last week, a promising development. Baltimore's Torrey Smith leads the AFC with 111 receiving yards per game.
The pick: Packers 28, Ravens 24
Bengals (3-2) at Bills (2-3)
1 p.m. Bengals by 6½, 41½
The Bengals defense gets kudos for stopping Tom Brady's streak of games with a touchdown pass at 52 in last week's 13-6 win over the Patriots. How many touchdown runs do you think Cincy's BenJarvus Green-Ellis (above) has since the start of 2010? Answer's 33, tied for fourth in the NFL. QB Thad Lewis, signed off the practice squad, makes his second career start, so the Bills need help from RB C.J. Spiller and RB Fred Jackson. Buffalo's Mario Williams has 7½ sacks, 6½ off of his career high set in 2007.
The pick: Bengals 24, Bills 10
Lions (3-2) at Browns (3-2)
1 p.m. Lions by 2½, 44
In the teams' last meeting, in 2009, then-rookie Matt Stafford (above) passed for five touchdowns, including the winner as time expired in a 38-37 Lions win. Detroit has, perhaps, the league's best 1-2 dual-threat running backs in Reggie Bush and Joique Bell, who have combined for more than 400 yards rushing and another 400 receiving on 37 catches. The Browns have won three straight, but QB Brandon Weeden has two touchdowns among 110 passes. And Willis McGahee is averaging just 2.6 yards per carry.
The pick: Lions 31, Browns 21
Rams (2-3) at Texans (2-3)
1 p.m. Texans by 7½, 42½
Eli Manning is worse, but Matt Schaub (above) is despised in Houston. After six touchdowns in a 2-0 start, he has two and six interceptions in an 0-3 slide, including at the Ravens and 49ers by a combined 64-12. Houston is No. 1 in total defense (260 yards per game). But thanks to Schaub's four pick-sixes, it is 25th in scoring. Rams QB Sam Bradford needs help from the run game, and rookie Zac Stacy had 78 yards last week. He's still waiting for first-rounder Tavon Austin to improve on his 6.8 yards per catch.
The pick: Texans 21, Rams 14
Raiders (2-3) at Chiefs (5-0)
1 p.m. Chiefs by 8, 41
Can Oakland, winners of six of the past eight in the series, hand the Chiefs their first loss … on their homefield? The Raiders won four games last season, but two were against Kansas City, including 15-0 in December. Raiders QB Terrelle Pryor, above, is playing well — 502 passing yards, 72 percent completion rate and three touchdowns without an interception — over the past two games. The Chiefs are undefeated because they have committed five turnovers in five games. They're an NFL-best plus-10 in turnover margin.
The pick: Chiefs 28, Raiders 13
Steelers (0-4) at Jets (3-2)
1 p.m. Pick 'em, 41
These are the AFC's worst in turnover margin. Pittsburgh seeks its first takeaway to offset 11 turnovers; the Jets are minus-9 with an AFC-worst 12 turnovers committed. Expect the Steelers to lean more on rookie RB Le'Veon Bell (above), who had two touchdowns in his debut after missing three games to injuries. Steelers WR Antonio Brown (412 yards) shouldn't be a new name. He had 1,108 yards in 2011 and five touchdowns in 2012. Jets DE Muhammad Wilkerson, a 315-pounder, has four sacks.
The pick: Jets 21, Steelers 14
Panthers (1-3) at Vikings (1-3)
1 p.m. Vikings by 2, 44
Ex-Buc Josh Freeman will be the inactive No. 3 QB for the Vikings and behind Christian Ponder. But how will starter Matt Cassel play looking over his shoulder? The 2-year-old son of RB Adrian Peterson (above) died Friday. Peterson is expected to play. But in any case, emotions will be high on the Vikings sideline. Carolina's only win is against the winless Giants, and it has scored 12 points in its other three games. Ted Ginn is averaging 20.1 yards per catch, third in the NFL among players with 10-plus receptions.
The pick: Vikings 28, Panthers 24