Packers at Jaguars, 1
Line/OU: Packers by 5; 471/2
There's no shortage of optimism for Jacksonville's future after an offseason that revamped the roster with shrewd draft picks and expensive free agents. But while losing teams rebuild, winning teams reload. The Packers have done that with the return of Jordy Nelson, the team's top WR, who missed last season because of injury. There has been much conversation around RB Eddie Lacy's offseason weight loss.
Raiders at Saints, 1
Line/OU: Saints by 1½; 51½
The Raiders have built a team that seems on the verge of big things, thanks to LB Khalil Mack, who is the rare type of player who single-handedly changes games. His 15 sacks last season felt like the beginning of something special. Oakland is also strong on offense, with QB Derek Carr having built a strong rapport with WRs Amari Cooper and Michael Crabtree, and Latavius Murray has shown flashes of brilliance at RB. The Saints will be a threat as long as QB Drew Brees chooses to play, especially when they are at home, but there is little reason to believe they suddenly know how to play defense.
Bills at Ravens, 1
Line/OU: Ravens by 3; 44½
The Bills showed some promise for a bright future last season, but the team failed at the thing coach Rex Ryan is known for: quality defense. Ryan brought in his brother Rob to help right the ship, and while the preseason was not all that encouraging, Week 1 could see some improvement as two rookies are expected to start on the left side of Baltimore's offensive line.
Chargers at Chiefs, 1
Line/OU: Chiefs by 6½; 44½
Whether Jamaal Charles is ready to return from the knee injury he endured last season hardly seems to matter in the short term as Charcandrick West and Spencer Ware are more than capable of piling up rushing yards against San Diego.
Bears at Texans, 1
Line/OU: Texans by 6; 43½
Brock Osweiler might or might not succeed as a starting QB in the NFL — the Broncos certainly seemed skeptical when they let him walk away despite not having another experienced QB on the roster — but everyone is sure that at 6 feet 8, he is very tall. Coach John Fox's Bears also have a lot of questions in terms of ability, and are not nearly as tall.
Vikings at Titans, 1
Line/OU: Vikings by 2½; 40½
Anyone clamoring for Sam Bradford to start, or come on in relief, for Minnesota this week might be overestimating the difference between him and Shaun Hill, but either QB can probably manage enough offense to fend off a Titans team that has some promising pieces but is a long way from being dangerous.
Browns at Eagles, 1
Line/OU: Eagles by 3½; 41
The Browns were so sure that Carson Wentz was not a viable solution at QB that the team traded away the No. 2 pick in the draft rather than select him. It will be very awkward if his first game as a rookie quarterback results in a win over the Browns.
Bengals at Jets, 1
Line/OU: Bengals by 2½; 42
At full strength, the Bengals are a better team than the Jets, but they will play without standout LB Vontaze Burfict, who is suspended for repeated violations of the league's safety rules, and star TE Tyler Eifert, who is recovering from offseason ankle surgery. The Jets, meanwhile, begrudgingly retained Ryan Fitzpatrick after a franchise-record 31 TD passes last season. The addition of Matt Forte, a two-time Pro Bowl selection, to the running game should help balance the offense.
Dolphins at Seahawks, 4
Line/OU: Seahawks by 10½; 44½
Olivier Vernon left for New York, Cameron Wake is working his way back from an Achilles tear and Ndamukong Suh seemed far less dominant in his first season in Miami. But even with those things all being true, a strong game from the Dolphins' defensive line against a vulnerable Seattle offensive line is the best hope of this game not being embarrassing.
Lions at Colts, 4:25
Line/OU: Colts by 3; 50½
Calvin Johnson's surprising retirement not only left the Lions without their No. 1 WR, it will also force a trial by fire for Golden Tate, who thrived as Detroit's No. 2 last season but may have been benefiting greatly from Johnson's presence. As Detroit contemplates a post-Johnson world, the Colts are mostly hoping QB Andrew Luck can put his health concerns behind him.
Giants at Cowboys, 4:25
Line/OU: Pick; 46½
The good news for Dak Prescott, a rookie who will begin the season as the Cowboys' starter because of a back injury to Tony Romo, is he can hardly do worse than Romo's backups did last season when they were 1-11 in place of the Pro Bowl QB. The even better news is he might not be asked to do much, as Dallas' impenetrable offensive line should have a fairly easy time opening wide holes for rookie RB Ezekiel Elliott.
Patriots at Cardinals, 8:30
Line/OU: Cardinals by 6; 46
It will take time to determine if it was wise for New England to trade Chandler Jones to the Cardinals, but in Week 1, it will almost assuredly haunt the Patriots. The linebacker will be wreaking havoc as part of a stout Arizona defense that will try to make life miserable for Jimmy Garoppolo, New England's backup QB who has been forced into a starting role because of Tom Brady's suspension. The Patriots have to hope Garoppolo can win at least two games in Brady's four-game absence.
Steelers at Washington, 7:10 Monday
Line/OU: Steelers by 3; 49½
Steelers WR Antonio Brown and Washington CB Josh Norman, both All-Pros, will face off for the first time since 2014 when Norman was with Carolina. Pittsburgh RB Le'Veon Bell is serving the first of a three-game suspension for violating the NFL's substance abuse policy. Washington's Kirk Cousins has thrown 232 regular-season passes at home without an INT.
Rams at 49ers, 10:20 Monday
Line/OU: Rams by 2½; 42½
The Rams, playing their first game as a Los Angeles franchise since leaving for St. Louis after the 1994 season, have won just one of their past eight trips to San Francisco. There will be several other firsts: Rams QB Case Keenum will start the first season opener of his career, and Chip Kelly will coach his firstirst game with San Francisco. 49ers QB Blaine Gabbert will start his first opener since 2013 with Jacksonville.