GIBSONTON — Winless host East Bay (0-5, 0-1) struck for the first score, but the Terriers (4-2, 1-0) poured it on from there, scoring 35 unanswered points against their Class 4A, District 9 rival.
Hillsborough, which led just 10-6 at halftime, got on track in the second half behind Tim Randolph, who rushed for a game-high 131 yards.
"The whole season's been like that," Hillsborough coach Earl Garcia said. "If we started the game later we'd be undefeated."
Dante Evans finished off East Bay's first-quarter, 10-play, 82-yard drive with a 1-yard plunge.
But Randolph went 62 yards for a TD, and Jamie Knott and Eric Bass added scoring runs for the Terriers, who also got a Jeremy Agrinzonis scoring pass to Gerald Pearson and a 50-yard field goal from Mattias Ciabatti.
Steve Lee, Times correspondent