LAKELAND — Marcus Stone rushed for 141 yards, including a 4-yard touchdown during the first quarter, for the Vikings.
The Mustangs (1-7) had nothing to lose going into the game and tried to beat the Vikings (5-3) through the air.
They threw the ball 34 times, completing 12 passes for 183 yards.
Going into the fourth quarter, Lakeland Christian was up 14-13. And Northside Christian threatened to take the lead.
But the Vikings ended the comeback attempt with an interception by Buddy Welch.
Then Ryan Miles scored on a 1-yard run with 1:12 left that sealed the victory for the Vikings.
"They put a lot of pressure on us," Vikings coach Bobby-Dan McGlohorn said about the Mustangs.
"When we had to, we made plays. And that was the difference in the ballgame."
Fort Myers Gateway 28, Shorecrest 27: The Chargers rallied in the fourth quarter with two touchdowns but missed an extra point, which proved costly. Hunter Tremaine scored on three short runs.