MIAMI — Tight end Charles Clay outran a pursuing linebacker, juked past two defensive backs and left them all sprawling as he scored the Bills' first touchdown barely three minutes into the game.
The rout was on.
Tyrod Taylor threw for 277 yards and three scores in his first NFL road start and the Bills embarrassed the Dolphins 41-14 Sunday.
Buffalo totaled 429 yards, intercepted Miami quarterback Ryan Tannehill three times in the first half and led 27-0 before Miami scored late in the third quarter.
Taylor said the fast start was critical.
"We definitely know the challenges of the first road game — taking the crowd out of it," he said. "Mostly it was just going out there and executing."
Buffalo bounced back from a dismal loss at home to New England. The Dolphins, who began the season with high hopes of ending a seven-year playoff drought, fell into last place in the AFC East with their second consecutive loss.
"It certainly starts with me, the accountability," said Miami coach Joe Philbin, who began the year with little job security. "I take responsibility. … We'll look at everything we're doing. There's no magic potion. If I had a magic potion, I would have brought it out earlier."
The loss was the most lopsided in a home opener for the Dolphins, in their 50th season.
Buffalo improved to 5-2 against Miami over the past four years. The Bills are 18-26 against everyone else in that span.
The victory was especially sweet for former Dolphins Clay and Richie Incognito, who were co-captains for Buffalo.
Clay, whose touchdown reception went for 25 yards, signed as a free agent after four years with the Dolphins. Incognito played in Miami for the first time since his career was derailed for a year and a half when he was implicated in the Dolphins' bullying scandal.
Another ex-Dolphin, backup Bills receiver Chris Hogan, added a final insult when he caught a 38-yard touchdown pass in the fourth quarter.
"There's only one way to go — up," Miami tight end Jordan Cameron said. "You can't get any lower than this. We're going to find out a lot about each other, a lot about this team this week."