BALTIMORE — The Orioles hit four home runs in the first inning Friday before recording their first out, the first time that has happened in the majors' modern era, then went on to lose 15-8 to the Astros.
Adam Jones led off with a home run, Hyun Soo Kim singled, Manny Machado snuck one over the 410-foot sign in center, and Chris Davis and Mark Trumbo followed with homers.
Jose Altuve homered and had five RBIs for Houston, and George Springer went 4-for-5 with a homer.
Baltimore surrendered a season-high 15 runs and 18 hits.
INDIANS 3, BLUE JAYS 2: Tyler Naquin hit a game-ending inside-the-park homer, sprinting around the bases to cap a two-run rally in the ninth inning as host Cleveland stunned Toronto. The Blue Jays took a 2-1 lead into the ninth and Roberto Osuna retired the first batter, but Jose Ramirez tied it with a home run. Naquin followed with a drive that hit the top of the rightfield wall, above the leap of Michael Saunders. The ball caromed away at an angle and centerfielder Melvin Upton retrieved the ball, but fell down as third base coach Mike Sarbaugh waved Naquin home. Naquin stumbled in and scored with a head-first dive far ahead of second baseman Devon Travis' relay.
RED SOX 10, TIGERS 2: David Ortiz homered and Rick Porcello returned to Comerica Park with seven strong innings for visiting Boston. Porcello, who spent the first six seasons of his career with the Tigers before moving to Boston before the 2015 season, pitched in Detroit for the first time since the trade. Michael Fulmer's Rookie of the Year campaign hit a snag as the Red Sox got a career-high six runs off him in 52/3 innings. Ortiz hit his 22nd career homer at Comerica Park. Ortiz has hit more homers in Detroit than in any other ballpark outside the AL East.
MARLINS 6, PIRATES 5: Robert Andino hit a tiebreaking single in the ninth and visiting Miami won when Fernando Rodney got Andrew McCutchen to ground into a double play with the bases loaded.
Around the majors
TWO PLAYERS CLEARED: Philadelphia's Ryan Howard and Washington's Ryan Zimmerman were cleared by Major League Baseball of allegations they used human growth hormone. Pharmacist Charlie Sly claimed in an Al-Jazeera America documentary that the two used HGH. Sly, who worked as an intern at an anti-aging clinic, later recanted. MLB said the players cooperated with its investigation and Sly did not. Howard and Zimmerman denied the allegations and filed defamation suits against Al-Jazeera in January.
CUBS: Right-hander John Lackey went on the 15-day disabled list (strained right shoulder). Right-hander Hector Rondon, who has a team-leading 18 saves, also went on the 15-day DL (strained right triceps).
ROCKIES: Former Rays reliever Chad Qualls was reinstated from the 15-day disabled list. He had colitis.
Yankees: Right-hander Nathan Eovaldi had surgery to repair two tears in his elbow.