PITTSBURGH — Gabriel Landeskog redirected a shot by Nathan MacKinnon past Marc-Andre Fleury 22 seconds into overtime to lift the Avalanche by the Penguins 4-3 on Monday night.
Landeskog tied the score with 6:32 left in regulation with a power-play goal and his second of the night handed the Stanley Cup champions their first loss of the season.
Jarome Iginla and Patrick Wiercioch also scored for Colorado, which never led until Landeskog's winner. MacKinnon had two assists and Calvin Pickard stopped 28 shots.
Matt Cullen had a goal and an assist for the Penguins; Phil Kessel and Trevor Daley also scored. Fleury had 27 saves but the Penguins failed to become the first reigning Cup winner since the 1997-98 Red Wings to start 3-0.
The Penguins have still picked up a point in each of their first three games and are surviving just fine without captain Sidney Crosby, who remains out indefinitely after a concussion. Pittsburgh edged Washington and Anaheim to open the season behind sharp play from Fleury and Kessel.
Still, the Avalanche remained perfect since first-year coach Jared Bednar took over in August after Patrick Roy's abrupt departure. Colorado won all six of its preseason games and slipped by Dallas 6-5 in its season opener on Saturday behind Joe Colborne's hat trick.
Game highlights: For the third straight game, Chris Kreider had a goal and an assist as the host Rangers beat the Sharks 7-4. Kreider, who signed a four-year, $18.5 million contract on July 22, has three goals and three assists in New York's first three games. … Mike Green scored three times for his first hat trick and Darren Helm had two goals to help the Red Wings beat the Senators 5-1 in their last home opener at Joe Louis Arena. Green scored twice in the first, then his third goal restored a three-goal lead with 6:36 left in the game. … Four Bruins scored and Tuukka Rask saved 34 of 35 shots as Boston defeated the host Jets 4-1.