Sam Bradford was running out of bounds when a shove sent him tumbling.
Reggie Wayne was wide open when he turned to catch a low throw and crumbled to the turf.
Two seemingly harmless plays turned out to be quite costly. Bradford and Wayne each tore an anterior cruciate ligament in their knees and will miss the rest of the season.
Bradford's injury is a huge blow to the Rams, who will turn to backup quarterback Kellen Clemens.
Wayne's injury dampened the Colts' spirits after a big win over Peyton Manning and the Broncos.
"I have great respect for what he does on the field, but just as genuine concern for him as a person," Clemens said of Bradford, hurt when he was pushed by the Panthers' Mike Mitchell late in the fourth quarter.
Bradford tore his left ACL. The former No. 1 overall pick had 14 touchdown passes and four interceptions in his fourth season.
Wayne tore his right ACL in the fourth quarter. The soon-to-be 35-year-old receiver had played in 189 straight games and led his team with 38 catches and 503 yards.
"Looking back at it again today, there was really no one within 30 yards of him," quarterback Andrew Luck said. "He probably would have scored if I actually give him a decent ball. I feel somewhat responsible for the whole thing."
The Bears also suffered big losses. Quarterback Jay Cutler will miss at least four weeks after tearing a muscle in his groin against Washington. Pro Bowl linebacker Lance Briggs will be out around six with a small fracture in his left shoulder.
In other injury news:
• Texans Pro Bowl linebacker Brian Cushing is out for the season with a left knee injury that will require surgery.
• The Packers lost tight end Jermichael Finley to a significant neck injury in their win over the Browns.
• Eagles quarterback Nick Foles sustained a concussion in a loss to Dallas, and Michael Vick is still recovering from a hamstring injury.
MERIWEATHER SUSPENDED: Redskins free safety Brandon Meriweather, flagged twice for hits on defenseless receivers Sunday against the Bears, was suspended for two games by the NFL.
HARVIN TO PRACTICE: Seahawks wide receiver Percy Harvin is expected to practice today after missing the first seven weeks of the season following hip surgery.
DOLPHINS DEAL FOR OT: Miami acquired tackle Bryant McKinnie, a former Hurricane, from the Ravens for a conditional late-round pick.
HERNANDEZ CASE: Judge Susan Garsh, who is presiding over the Aaron Hernandez murder case in Fall River, Mass., rejected the prosecutors' request to step aside because of what they called bias in an earlier case.
DOUGLAS TRIAL: Former NFL defensive end Hugh Douglas pleaded not guilty to charges he assaulted his girlfriend at a Hartford, Conn., hotel.
FALCONS: Running back Steven Jackson, out four games with a hamstring injury, hopes to practice Wednesday.
JAGUARS: Coach Gus Bradley left the team after his father's death. Roy James Bradley died Sunday at age 85.
SAINTS: Linebacker Jonathan Vilma returned to practice, the first step in a possible return to game action after left knee surgery.