Sex therapy pioneers Dr. William Masters and Virginia Johnson, who revolutionized the discipline and developed new treatments for sexual dysfunction, are filing for divorce after 21 years of marriage.
A spokesman for the couple said Wednesday the decision was based on a differences in goals.
Masters, 76, and Johnson, 67, will continue a 35-year association with the Masters & Johnson Institute in St. Louis, the spokesman said.
Their most famous books are Human Sexual Response, published in 1966, and Human Sexual Inadequacy, published in 1970. Their current research work involves sexual trauma.
Their pioneering work made the couple the "first family" of sexology.
"If you can't communicate in bed, you probably can't communicate in marriage," Masters once said.
The couple developed new clinical prescriptions for treating such sexual problems as frigidity, impotency and premature ejaculation.