The Brewers and Houston Astros combined to use 15 pitchers before Henry Blanco's sacrifice fly in the 16th gave Milwaukee a 6-5 victory in a 5-hour, 39-minute game.
"This game is devastating for us," said Houston manager Larry Dierker, who was ejected in the 13th by plate umpire Mike Winters. "We don't have anything left for the next couple games. If we could have won it, it would have been inspirational."
Brewers manager Davey Lopes said: "It's difficult because you used everybody. You don't worry about tomorrow until it gets here. If you've got a chance to win a ballgame, you've got to go out and try to win it. Tomorrow, you look for your guy to go long into the game to alleviate that."
Marquis Grissom opened the 16th with an infield single off Chris Holt, the eighth Astros pitcher and the scheduled Thursday starter. After Jose Hernandez struck out, Lyle Mouton singled to right and Grissom moved to third.
Blanco's fly was dropped by Roger Cedeno at the rightfield line and Grissom scored to win it for the Brewers, who left 19 on base. Blanco was credited with a sacrifice on his hit, although Cedeno committed an error.
Horacio Estrada, the seventh Brewers pitcher, pitched two innings, allowing two walks and no hits.
Brewers reliever David Weathers gave up three consecutive singles to open the eighth to tie it 5-5. Richard Hidalgo bounced into a double play, Mitch Meluskey walked and Tim Bogar grounded out.
After Weathers' problems, five Brewers pitched 8 scoreless innings.