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MISSISSIPPI 59, NOTRE DAME 56: The smallest man in the game made the biggest shot.

Jason Harrison, Mississippi's 5-foot-5 point guard, sank a three-pointer with 46 seconds left as the shot clock ran down, boosting the Rebels past the Irish. Mississippi advanced to the Sweet 16 for the first time.

Harrison connected to make it 57-55 after the Irish had their first lead of the second half on Ryan Humphrey's 10-footer.

"I looked at the shot clock and it had eight," Harrison said. "It's one of those shots you dream about. I knew I had to make a play. I hadn't made a play in a long time."

Mississippi coach Rod Barnes admitted a lot of college coaches wouldn't even have bothered to recruit Harrison.

"I don't mind taking a chance on somebody when they have great character," Barnes said. "Size is the most overrated thing in basketball."

Emmanuel Wade made a free throw with 22 seconds left for Mississippi, and Matt Carroll answered with a free throw for Notre Dame, which was chasing its first Sweet 16 appearance since 1987.

With 18 seconds left, Sanders missed the front end of a one-and-one, but he blocked Carroll's attempt at a score-tying 10-footer.

Troy Murphy, Notre Dame's two-time All-American forward, had 17 points but was just 1-of-7 in the second half.

"They made me catch the ball in spots where it was harder for me to score, about 20-22 feet out," Murphy said. "They did a heck of a job."

He was noncommittal when asked if he'll skip his senior season.