Jefferson's John Jones will receive a financial aid package to play at Division III Elmhurst (Ill.) College.
The 5-foot-7, 175-pound Jones caught 15 passes and scored seven touchdowns last year while playing primarily as a third-down back and blocking fullback.
He started at free safety as a junior.
Sickles' Alana Singleton has signed a scholarship with South Florida, where she will compete in the discus, shot put, hammer and javelin.
Singleton, who placed eighth in the discus at the Class 6A state meet, has a personal-best discus throw of 127 feet, 3 inches.
She said she also considered offers from Central Florida, Florida Atlantic and Jacksonville.
"USF is in a great conference, and I feel can grow there," she said.
"I really think the coaches at USF can take me to the next level."