The Dolphins bloodied Peyton Manning, then knocked out the Colts.
Miami recovered a fumble on the only Colts offensive play Manning missed Sunday and followed that by driving 59 yards for a touchdown to rally for 10 fourth-quarter points and a 27-24 win.
"We knew they would be tough on the run, but it gave us an opportunity to throw downfield," coach Dave Wannstedt said.
Manning's counterpart, Jay Fiedler, had a big day, completing 17 of 29 for 259 yards and two touchdowns as he led the Dolphins to their fourth straight win in Indianapolis and their third straight comeback at the RCA Dome.
The Colts lost their top tackler, linebacker Mike Peterson, with a torn knee ligament, and Manning needed X-rays to make sure his jaw wasn't broken.
Manning, who has never missed a start in his four-year career, took a helmet-to-helmet shot from Dolphins defensive end Lorenzo Bromell midway through the fourth quarter _ a hit for which Miami was penalized. Manning came out of the game spitting blood.
Replacement quarterback Mark Rypien did not make a clean handoff to Dominic Rhodes, and Jason Taylor recovered to set up the winning drive.
Afterward, Manning was feeling the effects.
"I don't have much to say, because I've got to get X-rays and make sure it isn't broken," Manning said with gauze packed into his jaw. "It could be."
Miami took advantage of two late turnovers _ a Manning interception and the fumble _ to rally.
After the fumble, Fiedler needed seven plays to find an uncovered Chris Chambers on a 29-yard touchdown for the winner with 7:44 to go.
"You're always just waiting for the ball to come down when you're out there by yourself," said Chambers, who had three receptions for 113 yards and two touchdowns. "Jay made a great throw and a great read."
Miami's ground game, which has struggled in recent weeks, churned out 134 yards, including a 56-yard touchdown from Travis Minor that gave the Dolphins a 7-3 lead early.
But Indianapolis, which trailed 17-10 at halftime, turned the tables on Miami early in the second half. David Macklin's diving interception of Fiedler gave the Colts an opportunity, and three plays later Manning hooked up with Marvin Harrison on a 13-yard touchdown. Jeff Ogden's fumbled punt return offered another chance, and Manning found Harrison on a 40-yard touchdown to give Indianapolis a 24-17 lead with 8:06 left in the third quarter.