Cody Pickett's record-breaking day assured the Huskies of at least a break-even season and some bragging rights.
Pickett threw for 316 yards and four touchdowns and set the Pac-10 record for single-season passing yardage in Washington's 42-14 victory over Oregon on Saturday.
Pickett increased his total to 3,818 yards to surpass Ryan Leaf, who threw for 3,637 yards for Washington State in 1997.
Pickett also has 305 completions this season to top Steve Stenstrom's Pac-10 mark of 300 for Stanford in 1993.
"I'm proud of him," coach Rick Neuheisel said. "But I think he'd trade it all in for an unblemished record."
With one game left, the win helped the Huskies avoid their first losing season since 1976. They play conference leader Washington State next.
The Ducks were ranked sixth after a 6-0 start, but they have lost four of the past five. Oregon had not lost its home finale in its past nine seasons.
"That was humbling," center Dan Weaver said.
Though Washington has had a disappointing season, the Huskies retained some dignity with the victory over the Ducks, their Northwest rival for a century.
The series between the teams, which took a hiatus last season, has been contentious at times. Two seasons ago the Ducks handed the Rose Bowl-bound Huskies their only loss of the season.
This year, the team celebrated with fans in Autzen Stadium long after the game.
"We earned this win and we had fun doing it," defensive tackle Terry Johnson said.
Pickett also set a school record with 467 career completions, surpassing Damon Huard's mark of 458 (1992-95). Pickett's 25 touchdowns this season pass Huard's school record of 23 in 1997.
"We came in here, played in a hostile environment and got a win," Pickett said. "It's a great feeling."
Jason Fife completed 10-of-29 for 170 yards and two touchdowns.