Venus Williams was upset 6-4, 7-6 (7-5) by 25th-seeded Lisa Raymond, a former Gator, in the third round of the Australian Open.
The third-seeded Williams saved one match point with a backhand crosscourt winner, but put a forehand return wide on the next point to end the match in 1 hour, 29 minutes.
Williams was sidelined with an abdominal injury for six months and was returning to tournament play for the first time since Wimbledon.
For Raymond, a former top-ranked doubles player, it was her first win over Williams.
The upset was a rarity in what was previously an uneventful day.
Wimbledon champion Roger Federer routed teenage wild-card entry Todd Reid 6-3, 6-0, 6-1 to advance to the fourth round. Federer, 22, seeded second, dropped serve in the fifth game of the first set, then reeled off 14 consecutive games to win the first two sets and take a 4-0 lead in the third.
Reid, 19, struggled through the second round, vomiting during a grueling five-set win over Armenia's Sargis Sargsian. And Federer didn't give him any reprieve, firing 31 winners.
"I played well, had my difficulties in the start, but it went better in the end," Federer said. "I'm just happy to be again through to the fourth round."
Top-ranked Andy Roddick had little trouble as well. He posted a 6-2, 6-0, 6-2 win over Taylor Dent, who called the loss "without question, the worst tennis experience of my entire life. I wasn't tanking out there. I was busting my butt. It was embarrassing, absolutely embarrassing."
Dent found relief nowhere. While Roddick punished him on the court, a heckler berated him from the stands.
"The lady said, "Come on, Taylor, I paid a lot of money for these seats,' " he said. "I said, "It's costing me a lot of pride to stay out here.' "
Roddick was hardly about to spare his friend and potential U.S. Davis Cup teammate.
"The thing is you're so paranoid that _ okay, at least the way my mind works _ you're up a break in the third, he breaks back, you're on serve, it's a battle again," Roddick said.
Defending champion Andre Agassi was equally overpowering. The eight-time Grand Slam champ routed Thomas Enqvist 6-0, 6-3, 6-3 to extend his tournament winning streak to 24 matches.
"I feel like I did everything I was looking to do," Agassi said.
Top-ranked Justine Henin-Hardenne survived her first serious challenge, losing her serve twice in the second set before taking four consecutive games to beat Svetlana Kuznetsova 6-2, 7-5.
NO QUIT IN MARTIN: Todd Martin was a long way from the New Hampshire primary. The 33-year-old American had just lost a third-round five-setter to Marat Safin when he was asked about a possible political career. He was commended for his intelligence and eloquence, and it was suggested he might have had a shot for the Democratic presidential nomination if he had made his move earlier. "If I were a Democrat," Martin said, "I've got a couple of years to wait. In the States, we need to be 35 to be president, so maybe 2008. Watch out." Martin said he's not looking to retire. "I'm not at all anxious about what comes after tennis," Martin said. "But I've got plenty of options ranging from staying real involved in the sport, preferably in development, to being Mr. Mom and letting my wife pursue her career."
LINDSAY LEERY: Lindsay Davenport has won three Grand Slam singles titles, and she knows she'll have to play a lot better if a fourth is to come here. Davenport beat Laura Granville 6-4, 6-0 to gain the fourth round, coming from 4-1 down in the first set.
"Right now, I haven't won a Slam in four years," she said. "I'm going to have to do something that I haven't done in the last year or two, to be able to be in the top two or three contenders." After winning the Australian Open in 2000, Davenport lost in the final at Wimbledon and the U.S. Open. "I've got to make some big wins now if I want to expect to get back to that position," she said. "Hopefully, it will come sooner rather than later."
PAES RETURNS: India's Leander Paes took another step in his comeback from a nonmalignant brain lesion that sidelined him for five months. He and Martina Navratilova won mixed doubles, beating Chris Haggard of South Africa and Emilie Loit of France 6-3, 7-6 (7-3). Navratilova captured a record-tying 20th Wimbledon title last year by winning the mixed doubles with Paes. The pair also won the Australian title last year. Paes was treated last year in Orlando. He first noticed symptoms, such as dizziness, during the mixed doubles quarterfinal at Wimbledon.
"I actually came up to hit a smash and when I landed on the ground, something must have shaken inside my brain because I lost all sight," Paes said. "I lost all control of my balance and I was falling down." He thanked Navratilova for helping him during the recovery. "The last six months have been a trying time, and she's been such an inspiration to me," he said.
SANTORO FINED: Fabrice Santoro was fined $1,500 for spitting in the direction of an on-court official during his loss to Mark Philippoussis. He was cited for for unsportsmanlike conduct by the ITF for his actions after a disputed line call Thursday.
"I know him, and he's one of the politest kids that are out there," Australian Davis Cup captain John Fitzgerald said. "He obviously made a bit of a mistake."
MEN: Andy Roddick (1) def. Taylor Dent (27) 6-2, 6-0, 6-2; Andre Agassi (4) def. Thomas Enqvist 6-0, 6-3, 6-3; Sebastien Grosjean (9) def. Dominik Hrbaty 2-6, 6-4, 6-1, 6-3; Paradorn Srichaphan (13) def. Gustavo Kuerten (19) 6-3, 7-5, 6-4; Sjeng Schalken (16) def. Jurgen Melzer 7-6 (7-1), 6-4, 6-1; Robby Ginepri (32) def. Nicolas Escude 6-2, 6-3, 6-4
WOMEN: Justine Henin-Hardenne (1) def. Svetlana Kuznetsova (30) 6-2, 7-5; Amelie Mauresmo (4) def. Anabel Medina Garrigues 6-1, 6-2; Lindsay Davenport (5) def. Laura Granville 6-4, 6-0; Vera Zvonareva (11) def. Nicole Pratt 7-5, 2-6, 6-1; Mara Santangelo def. Eleni Daniilidou (19) 6-4, 5-7, 6-3; Fabiola Zuluaga (32) def. Jill Craybas 7-6 (7-5), 4-6, 6-2.
TODAY ON TV: Early rounds, noon ESPN2 (taped); 10 p.m. ESPN2.