Jeremy Hunt and Rodney Carney scored 15 each as Memphis won its fourth in a row Tuesday night, beating South Florida 66-53.
Antonio Burks added 13 points and five assists for the Tigers (13-4, 4-2 C-USA), who shot 23 percent from the field in the second half.
Terrence Leather led the Bulls (6-9, 0-4) with 15 points and 10 rebounds, and Bradley Mosley also had 15 points.
The only bump for Memphis came when USF, behind Leather, made a 10-1 run to cut it to 55-45 with 5:33 left. But the Bulls got no closer, dropping their fifth in a row on the road.
"I thought our zone made a big difference," USF coach Robert McCullum said. "It got us back in the game.
"Unfortunately, we did a poor job of rebounding out of our zone, so they got second and third shots. That was really the only downfall of the zone."
Memphis had eight steals in the first half.