Barry Bonds wasted no time getting to 701. He added another home run to his impressive total a day after hitting No. 700, but David Wells shut down the rest of the Giants into the eighth inning and Jay Payton hit a tiebreaking three-run shot in the seventh to lead the Padres to a 5-1 victory.
"If you want to make a name for yourself, you've got to challenge the best, go after him," Wells said. "Unless it comes from the dugout, I'm not going to walk anybody."
A tribute to Bonds was played on the main centerfield scoreboard before the game, and he received a long ovation when he jogged out to take his position in leftfield and again when he stepped into the batter's box.
He gave the crowd more to cheer about when he led off the second inning with a homer to right-center on the first pitch he saw from Wells, the 43rd homer of the season for the six-time MVP.
With the latest home run, Bonds, 40, moved into a tie with Ted Williams for 11th place on the all-time RBIs list with 1,839. He also took over seventh place on the career list for total bases from Carl Yastrzemski with 5,540 _ he began the year in 10th place, also passing Frank Robinson and Eddie Murray.
Bonds joined Hank Aaron (755) and Babe Ruth (714) in the 700 club Friday with a third-inning homer off the Padres' Jake Peavy.
On Saturday, Bonds also struck out in the fourth, grounded out in the seventh and struck out in the ninth _ he hadn't struck out twice since July 15 at Colorado and has struck out just 36 times this season.
The homer, which came on a hanging cutter, was about the only mistake Wells made.
"The difference was Wells," Giants manager Felipe Alou said. "He dominated our guys. Except for Barry's homer, it was a breeze for him."
Payton's big hit against Giants ace Jason Schmidt also made a difference _ the ball sailed over Bonds' head. Payton is 8-for-18 with two homers lifetime against Schmidt.
The other homer off Schmidt came July 22 this year and also was a three-run shot.
"Fortunately for us, this year we've done well against him," Payton said. "It's big. We have to come back every day. There's not much tomorrow for us."
The Giants lost for only the fifth time in 15 September games and had their six-game winning streak snapped. They began the day with a half-game lead over the Cubs in the NL wild-card race.
Wells beat the Giants for the second time in five starts against San Francisco this season. He left after 7 innings with two runners on _ having struck out five and not walked a batter. He allowed five hits.
"I tell you what, you can't have a better guy out there," Padres manager Bruce Bochy said.