Terrence Whitehead ran for 115 yards and scored two touchdowns, lifting host Oregon over Idaho, which was mourning the death of cornerback Eric McMillan. Idaho struggled all week with the loss of McMillan, who was shot Sunday in his Moscow, Idaho, apartment and died Monday.
A moment of silence was held for McMillan before the game and the Vandals played with "EM" stickers on their helmets.
Oregon, coming off a 31-7 loss at Oklahoma, quickly jumped on the outmatched Vandals and built a 34-3 lead late in the first half, topped by Kenny Washington's 2-yard scoring run.
Oregon kicker Jared Siegel set the school's career points record when an early point-after gave him 273 points. But his string of 98 straight successful PATs, 10 short of the Pac-10 record, was snapped when he missed late in the first quarter.