After falling behind early, Lakewood pulled away from visiting Boca Ciega and cruised.
The Pirates jumped out to an 8-0 first-quarter lead thanks to a safety and a 3-yard touchdown pass from Shaquille Bradford to Latavien Washington.
The Spartans then reeled off 20 unanswered points, the highlight being an 89-yard kickoff return for a touchdown by the versatile Bernard Reedy.
Boca Ciega closed the gap to six on an 11-yard touchdown strike from Bradford to Joseph Lynn.
But Lakewood quarterback Jermiel Douse hooked up with receiver Andre Taylor for a 49-yard touchdown that gave the Spartans a 13-point halftime cushion.
Reedy capped the night with a 37-yard run in the fourth quarter.