Calvary Christian High School in Clearwater closed its doors Friday after almost 100 students and five teachers called in sick with flu-like symptoms.
Executive pastor Dave Rice said the spreading flu virus has affected about 20 percent of the school's student body and five out of about 35 teachers on staff.
"We just decided it would be easier to give our constituents the day today so they can regroup over the weekend and come back full strength on Monday," he said.
Rice said the school has contracted with a company that they have used in the past for special cleaning projects. They are expected to disinfect and clean the building to be ready for school on Monday.
The school's closure has not had an impact on extra-curricular activities, he said.
"We're hoping everybody gets better and comes back strong on Monday," he said.
Pinellas County has been deemed a hotspot for flu cases with at least five reported outbreaks. Public school districts have sent guidance out to families urging parents to keep their children home if they are sick.