Local hospitals help identify better way to fight MRSA infections

Lesly Marsh, 31, an RN in the Largo Medical Center cardiac unit, helps Arlene Kister, 77, use one of the hospital’s new chlorhexidine gluconate bath wipes on Wednesday afternoon.
Lesly Marsh, 31, an RN in the Largo Medical Center cardiac unit, helps Arlene Kister, 77, use one of the hospital’s new chlorhexidine gluconate bath wipes on Wednesday afternoon.
Published May 30, 2013

A national study involving six local hospitals could answer a heated medical debate over how best to protect patients from the dangerous MRSA super bug.

Screening patients for MRSA and isolating those who have it is the most common strategy used today at hospitals. But it isn't the most effective approach, researchers found in the study published Wednesday in the New England Journal of Medicine.

Many more infections were prevented when the hospitals treated all intensive care patients — regardless of whether they had the MRSA bug — with an antimicrobial bath and nasal ointment.

This approach was tested at Largo Medical Center, one of the local institutions involved in the study through parent company Hospital Corporation of America, the nation's largest for-profit hospital chain.

The study involved 43 HCA hospitals and nearly 75,000 ICU patients, including those at Regional Medical Center Bayonet Point in Hudson, Brandon Regional Hospital, Medical Center of Trinity, South Bay Hospital in Sun City Center and Blake Medical Center in Bradenton.

The results could be a game changer in how hospitals combat MRSA, or methicillin-resistant Staphylococcus aureus, a type of staph bacteria that is not easily treated with antibiotics.

It's fairly harmless on the skin, but the bacteria can become deadly once it enters the bloodstream.

Hospital patients with open wounds and intravenous lines are especially vulnerable to severe infections, which have been blamed for as many as 19,000 U.S. deaths annually. More recent statistics from the U.S. Centers for Disease Control and Prevention, however, indicate MRSA infections are declining, especially in hospital settings.

But it remains such a scourge that HCA plans to roll out the most effective treatment identified in the study as standard practice in the adult ICUs of its 156 hospitals nationally, including 38 in Florida.

Researchers hope that others will follow.

"I think it's going to be a lively discussion," said Dr. Doug Holt, director of infectious disease for the University of South Florida's medical school and its affiliated practice at Tampa General Hospital. "There will be a lot of pressure because people sort of feel isolation fatigue."

Holt, who was not involved in the study, said most hospitals isolate ICU patients if they are found to have MRSA. They are placed in private rooms, with visitors and health care workers required to don gloves and gowns to enter. The idea is to limit the spread of the bacteria, typically found in the nose.

But the researchers found that these type of contact precautions, coupled with screening to identify MRSA carriers, aren't the best approach for preventing ICU infections, even though they are mandated in nine states. (Florida isn't one of them.)

In the study, hospitals were randomly assigned to three prevention strategies — screening and isolation; screening and isolation with MRSA treatment for the patient; and across-the-board treatment for all ICU patients.

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Treatment involved a daily bath with an antiseptic towel — which comes prepackaged and is slightly larger than a wash cloth — for five days. During that time, patients also received a nasal ointment medication twice a day.

In the group receiving universal treatment, researchers reported a 37 percent decrease in positive MRSA cultures.

They also saw a 44 percent decrease in all bloodstream infections, not just those resulting from MRSA.

"We've hopefully answered this critical question of whether we go after each super bug one by one by one and protect high risk people," said Dr. Susan Huang, an associate professor at University of California-Irvine medical school, the study's lead author. "We can treat them all and protect them all."

Because the study took place in community-based hospitals, as opposed to uniquely specialized and staffed academic institutions, she said, the practices identified easily could be implemented in hospitals nationally.

A study on the cost effectiveness is in the works, Huang said. But she estimated that the antiseptic towels would cost hospitals an extra $3 to $5 per day. The nasal treatment would run $3 to $35 dollars per course, depending on whether generics are used. And hospitals could eliminate the expense of screening their ICU patients for MRSA.

But the study did not address concerns, noted in an accompanying editorial in the New England Journal of Medicine, that widespread treatment could lead to more patients developing resistance to these drugs, especially the nasal medication used.

"It's like giving somebody antibiotics when they have a virus. It's overuse of antibiotics," said USF's Holt, who is also the director of the Hillsborough County Health Department, noting that the result could be an even harder-to-treat super bug. "You don't want to lose another bullet in your chamber because you overdid it."

He preferred to see hospitals look first at the widespread use of the antiseptic wipes, which Tampa General has been using with ICU patients since 2007. The towels are also used on patients coming in for surgery.

Yet at Largo Medical, the potential for more drug resistance doesn't trump the patient safety benefits, chief nursing officer Brenda Simpson said.

"The patient can feel relieved that they come into the hospital and not only are they preventing MRSA, but they also are preventing other bloodstream infections," she said, noting how easy it was to adopt a potentially life-saving practice. "It's probably one of the easiest things to do."

Letitia Stein can be reached at (727) 893-8330 or