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Global research sees statin benefits in lower risk patients

Published Apr. 3, 2016

CHICAGO — The first major research of its kind shows that cholesterol-lowering statins can prevent heart attacks and strokes in a globally diverse group of older people who don't have heart disease.

The results bolster recommendations in recent guidelines on who should consider taking the drugs.

The aim was to prevent heart problems using a statin alone, blood pressure drugs or a combination of the two. The three approaches are commonly used in high risk patients or those with evidence of heart disease. The patients in the study did not have heart disease and faced lower risks of developing it, and the statin approach worked best.

The research involved nearly 13,000 men and women from 21 countries on six continents. Most previous studies on heart disease prevention have been in white, North American patients with higher risks because of high blood pressure, unhealthy cholesterol levels or other conditions.

But with heart disease a leading global killer, causing 18 million deaths each year, there is a trend toward recommending preventive drug treatment to more borderline patients.

The benefits of this strategy were "seen in people from every part of the world," said study co-author Dr. Salim Yusuf, a professor of medicine at McMaster University in Hamilton, Ontario. "This is globally applicable."

The research was published online Saturday in the New England Journal of Medicine and presented at an American College of Cardiology meeting in Chicago.

Study sites included Canada, Europe, China, South America and South Africa. About 20 percent of patients were white.

Patients were at moderate risk because of age — men were 55 and older and women were at least age 60 — and because they had another heart disease risk factor, including obesity, family history or smoking. On average, their cholesterol levels were nearly normal and blood pressure was slightly lower than the cutoff for high blood pressure, which is 140 over 90.

They were randomly assigned to receive one of the treatments in low doses or dummy pills for almost six years. The drug treatments all reduced cholesterol and blood pressure levels but other results varied.

Statin-only patients were about 25 percent less likely to have fatal or nonfatal heart-related problems than those given dummy pills. Those in the combined drug group fared slightly better and the researchers credit the statin for the benefit.

Heart problems and deaths were relatively rare in the three study groups.

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