The Top 8 Best Nitric Oxide Supplements For Sale In 2022

The Top 8 Best Nitric Oxide Supplements
The Top 8 Best Nitric Oxide Supplements [ Photo ]
Published Jan. 21, 2022|Updated Jan. 21, 2022

Your body needs oxygen and nutrients to stay healthy and strong. Nitric oxide supplements dilate blood vessels and improve circulation, so you have enough energy for your workout, and for the rest of the day.

In this article, we will look at the best nitric oxide supplements and their benefits. We’ll also explore the science behind the most effective ingredients, why it actually works, and how it interacts with your body.

You’ll be able to make an informed choice about the best nitric oxide supplement for your needs, and find the best value and the most effective results.

The Top 8 Best Nitric Oxide Supplements

Nitric oxide supplements have become very popular lately, both among fitness enthusiasts or the general public who want to enjoy more energy and better performance the whole day (and night).

This has led to a surge of supplements from brands who want to take advantage of the trend. They have different prices, active ingredients, and reputation—but which ones really work, and which ones are just all buzz and marketing hype?

Don’t waste your money on ineffective products. We road-tested and read the reviews to pick the top 8 nitric oxide supplements in 2022.

Read on to find out which one is right for you.

#1. Magnify


This is by far the best nitric oxide supplement in the market today. It contains ingredients that are clinically proven to dilate blood vessels and improve blood flow—and with one of the highest concentrations, too.

Many people swear that it’s made a big difference in their workouts, daily energy levels, and overall health and well-being. While it’s not cheap, you get a lot of value for money because of the quality of the ingredients in each capsule.

Here’s what you can get from Magnify, the best nitric oxide supplement:

L-arginine Complex (1500 mg)

This compound has several clinical studies that prove its ability to boost nitric oxide levels, which will boost your performance in the gym and lower your risk for heart disease, heart attacks and stroke.

L-arginine also helps your body release growth hormones, which are important for building and repairing muscle and bulking up. If you lift heavy weights or going through heavy sports training, you need L-arginine to supercharge your recovery process.

Beetroot extract (1000 mg)

The beetroot extract enhances blood flow for better cardio-respiratory endurance. You’ll be able to power through longer, more strenuous workouts because your muscles receive more oxygen and nutrients. You’ll also feel less pain and recover faster.

Beetroot is also known to improve digestion and fight inflammation, and may even strengthen your lungs. So even outside the gym, you’ll feel better and stronger.

L-Citruline (1000 mg)

This is one of the most effective ingredients for increasing your body’s production of nitric oxide. It is easily absorbed by the body, and has additional benefits like improving the immune system.

Studies also show that it can improve performance and endurance—allowing users to do more reps or lift heavier weights, and feel less pain after the workout.

VASO6™ (400 mg)

Commonly known as pomegranate, this nutrient is rich in anti-oxidants and iron, and is a potent anti-inflammatory. This can help improve endurance, and lower soreness and pain after a workout.

L-Norvaline (300mg)

L-Norvaline is an amino acid derived from Valine, a branched-chain amino acid. It’s a unique compound that supports the body’s arginine concentrations. Arginine plays a crucial role in nitric oxide.

S7™ (150mg)

S7 is clinically proven to increase nitric oxide levels by as much as 230% . It is made from 7 different kinds of plant extracts, including green tea, turmeric, green coffee bean, tart cherry, blueberry, kale and broccoli.

S7 is one of the latest ingredients for boosting nitric oxide production. It is so potent that a small dose can make a big difference, so the 150mg in Magnify can already help you get an amazing pump.

Bioperine (10mg)

Bioperine is a black pepper extract that helps enhance the absorption of nutrients. It’s a great addition to the formula to make sure your body absorbs the other ingredients optimally.

Through this combination of ingredients, Magnify helps you get better workouts and faster results. It can even help give vascularity, or the look of “popped-up veins” even when your muscles are at rest.

This is one of the reasons why it gets incredibly high reviews, averaging 4.8/5 stars on its website and 4.1/5 stars on Amazon. You can buy this nitric oxide supplement from Amazon.

#2. Snap Nitric Oxide Beets


If you’re looking for an organic and natural nitric oxide supplement, then Snap is a good choice. It’s vegan, gluten-free, non-GMO and has no added sugar or caffeine.

It also tastes pretty good and is quite versatile. If you need a chance, you can add lemon slices or ginger water, or add it to your smoothie.

Snap has a high 4.3/5 rating on Amazon, with nearly 1,500 glowing reviews. It’s not just hype, either—this nitric oxide supplement has several features that make it popular among bodybuilders and general wellness enthusiasts.

Organic beet root powder

Beet root powder is full of nitrates and other nutrients that can improve circulation and blood flow, strengthen the heart, and maintain blood pressure. It can even help with brain neuroplasticity and cellular health.

Snap Nitric Oxide Beets only uses organic, non-GMO (genetically modified organisms) sources. If you’re concerned about additives and chemicals, this is the “cleanest” way to increase your nitric oxide levels.

Perfect ratio for improved muscle mass

This supplement contains the optimum balance of nitric oxide and branch chain amino acids for protein synthesis. You fuel your muscles with oxygen for a power workout, and then feed the muscle fiber with nutrients for repair and healing.

With regular supplement intake and exercise, you’ll soon burn that extra fat into strong, toned muscles.

Other useful ingredients

This product doesn’t just contain beet root powder – there’s also organic pomegranate juice, red spinach extract, and black pepper extract.

#3. Neo40 Professional


If you’re looking for a nitric oxide supplement to lower your blood pressure, then this has a good mix of nutrients. While it has lower concentrations than other supplements, it has less side effects and risks for people who are in their 40s or older.

But even if it’s “gentler” it’s still very effective. In fact, Neo40 even underwent clinical trials through a double-blind study at the Cedars-Sinai Institute.

The tests showed that after 30 days of intake, participants saw a 12-point drop in their systolic blood pressure, and a 6-point drop in their diastolic blood pressure.

Beetroot powder

Neo40 harnesses the power of beetroot to increase nitric oxide production and improve blood flow. It can also help with circulation, and symptoms like numbness or tingling in your feet and hands.

Hawthorn berry extract

This plant extract has been used for centuries in traditional Chinese medicine to lower blood pressure—and clinical trials have found evidence that it works.

In one study, people with type 2 Diabetes who took hawthorn berry supplements every day for 16 saw improvements in their diastolic blood pressure. Other tests done on mice found that the supplements can lower blood cholesterol and reduce liver inflammation.


It contains 428mg of L-citrulline, enough to improve your body’s production of nitric acid and enhance your blood flow. (If you are taking nitrates or other prescription medication for hypertension, consult your doctor about the best dose given your medical history.)

Vitamin B12

This nutrient helps break down homocysteine. This is a naturally occurring chemical in the body, but elevated levels have been associated with stroke, heart attack, and cardiovascular stress.

Vitamin C

While Vitamin C can help with blood pressure at high doses (approximately 500 mg), Neo40 only contains about 100 mg. However, it will support the immune system and can help with inflammation. To get your full RDA of Vitamin C, add citrus fruits to your diet.

Neo40 Professional comes in a lozenge form that you simply dissolve on your tongue. If you’re not fond of taking sports drinks—either because of the taste or concerns about calories—then this method of intake may be more appealing for you.

#4. Superbeets


If you like the taste and the health benefits of beets, but don’t have the time to regularly make smoothies, then add nitric oxide supplement to your shopping cart.

Convenient and diet-friendly

It’s made of dehydrated beets, in convenient powder form. Just add a teaspoon to water or any other fresh fruit drink. It only has 15 calories and 4 grams of carbohydrates, with no fat and very little salt. It also contains 50 mg of Vitamin C, which is already 83% of your daily requirements.

Delicious and refreshing taste

Some supplements can have an unpleasant chalky taste, especially if you’re not used to taking them. However, Superbeets has a fruity taste—a mix of beets and your choice of black cherry or apple.

Lowers blood pressure

While Superbeets has not gone through peer-reviewed clinical trials, one study funded by the manufacturer found that participants who took the powder for 4 weeks experienced a reduction in their systolic blood pressure.

This is consistent with other research done on beetroot juices in general. One study found that blood pressure drops about 3 hours after taking the juice.

The results are not permanent, thus requiring that you drink it every day to maintain results), but it shows that it can be part of a holistic, natural way of preventing blood pressure spikes.

Rich in antioxidants

Beets are very rich in anti-oxidants, which bind with free radicals that can cause ageing and increase the risk for cancer.

While you may buy this nitric oxide supplement primarily to improve blood flow and blood pressure, the additional protection against premature wrinkles certainly doesn’t hurt.

#5. Snap Nitric Oxide Booster


This is a pre-workout supplement to improve endurance and energy levels, and support muscle growth. The additional benefits for blood pressure and circulation can help people with health conditions prepare for exercise, and gradually become stronger and fitter.

Vital amino acids

The supplement contains L-citrulline and L-arginine, which are both clinically proven to improve the body’s nitric oxide production. This can help increase stamina and endurance, so you can increase your reps or find your second wind for the final sprint.

Higher energy levels, better blood circulation

L-citrulline and L-arginine improve blood flow, so your body gets enough oxygen and nutrients before, during and after your workout. A better workout means better results—and since you feel less muscle pain, you can give 100% each time.

Better blood flow benefits you outside of the gym, too. A user who suffered from neuropathy, or tingling in the feet, reported better blood circulation. Another user who is over 70+ years old said that he had better energy levels throughout the day.

90 day guarantee

Like all Snap products, this nitric oxide supplement comes with a guarantee. To get the best results, take the full dose for 90 days. If you have completed the regimen and feel that it has not met your expectations, you can apply for a refund.

#6. L-Arginine 3000


This supplement has one of the highest concentrations of L-arginine powder in a single dose. One capsule contains 3,000 mg of pure L-arginine—so you reap the full health benefits.

Greater stamina

L-Arginine is clinically proven to improve blood flow. You’ll feel the difference in your energy levels during workout—what athletes and fitness enthusiasts like to call “pump.” Power through long and difficult sets, and push through limits and plateaus.

Improved circulation

Proper blood flow ensures that all your muscles get the oxygen and nutrients that it needs. It reduces the strain on your heart, and facilitates repair and healing after a workout. That’s important for anyone, regardless of fitness level or activity—whether you lift heavy weights, run marathons, or like to Zumba.

Circulation is especially important for people who are just starting a fitness routine. If you’re too tired or out of breath after a workout, you may be tempted to quit. Nitric oxide supplements like L-Arginine 3000 can keep your energy (and motivation) flowing.

Lab-tested and certified organic

All products are made from high quality organic ingredients, and then lab-tested by a third party facility as part of quality control.

#7. Cellucor N03


This is one of the most affordable, budget-friendly nitric oxide supplement. One small can of the powder supplement costs about $20, and a bottle of 90 pills cost about $30 (or just thirty cents per pill!).

Effective ingredients

But even with its affordable price, Cellulor N03 can help improve gains and supercharge your workout. It is made of arginine nitrate (a power combination of L-arginine and nitrates). Each ingredient is already effective on its own, but fused together they can help you achieve unbelievable pumps.

The new and improved formula also contains the patented NItrosigine, which helps increase nitric oxide levels and promotes blood flow.

High customer satisfaction

This product has an average 4.7/5 star rating, with customers saying that it helped them that extra push to finish their sets, and did not have the side effects (light-headedness, nausea) that they experienced with other supplements.

Trusted, award-winning brand

Cellucor is known for its high-quality products, which range from supplements to drinks and even gear. If you’re buying supplements for the first time, and are generally new to performance boosters, it’s best to go to a brand you can trust.

#8. Toniq Beet Root Capsules


By now, you already know the benefits of beet root… but what if you hate the taste? Some people simply don’t like the earthy after-taste, or the strong flavorings used to mask it. If that’s the case, you can take Toniq Beet Root capsules.

Advanced extraction methods

When it comes to natural plant extracts, technology is the deal-breaker. Improper extraction can kill nutrients and reduce efficacy. It’s especially important for capsules, because the compounds have to be in a form that is easy for the body to absorb. Much can be lost during the delivery.

That’s why this nitric oxide supplement made it to our “Best of the Best” list. Toniq uses cutting edge extraction technology, which is why the capsule contains 4% nitrates—four times more the average amount found in most beet supplements.

High production standards

The facility is also GMP-certified and NSF-approved, which speaks of the quality control that is exercised during the manufacturing process. All batches are also individually tested by a third-party laboratory for quality and purity, so you know that you get what is promised in every bottle—without contaminants or impurities.

Affordable price

A bottle of 120 capsules costs about $18, proving that you don’t have to spend a fortune to buy a high-quality nitric oxide supplement.

If you’re on a tight budget, or want to try out a supplement for the first time, this is a good pick to start with.

Nitric Oxide Supplements Benefits

Nitric oxide is naturally found in the body. It is a vasodilator—or in layman’s terms, it relaxes the muscles in your veins and arteries, so they don’t narrow and restrict blood flow.

Nitric oxide plays a crucial role in maintaining the health of blood vessels, and regulating blood flow and blood pressure.

If your body doesn’t produce enough, it can affect your circulatory system, heart, physical performance and stamina, sexual performance, and even your immune system.

Nitric oxide supplements can ensure that your body maintains the required levels to stay alert, strong, and healthy. Here are some benefits:

Widens your blood vessels

Nitric oxide relaxes the blood vessels, in order to improve blood flow and maintain your blood pressure.

Unfortunately, age—and lifestyle habits like smoking, high-fat and high-cholesterol diets, and chronic stress—can lower your body’s nitric production, or tighten your blood vessels. This leads to:

  • High blood pressure. Unfortunately, it’s a vicious cycle. Low nitric oxide increases your blood pressure, and high blood pressure inhibits your body’s ability to effectively use nitric oxide.
  • Increased risk for heart attack and stroke. Your heart has to work harder to pump blood throughout your body. The symptoms of an over-exerted heart are very easy to miss, which is why even young and seemingly healthy individuals can suffer from a sudden stroke or heart attack.
  • Poor flow of oxygen and nutrients to organs and muscles. This can lead to low energy levels and concentration, and your body’s overall ability to “be at its best.”

They can also help prevent or manage hypertension and other cardio-vascular disorders. Numerous studies, including those published in journals like the Biochemical and Biophysical Research Communications, confirmed that taking one supplement a day can lower blood pressure and arterial stiffness.

Improves your performance in exercise and athletics

Nitric oxide improves how much oxygen is delivered to your muscles during exercise. This improves your stamina and endurance, and may lead to better overall performance.

One study conducted by the University of Exeter and published in the Journal of Applied Physiology found that participants who took a nitric oxide supplement were able to exercise for 20% longer.

It even improved their race time by up to 2%, which can be significant for elite athletes where even small gains can impact their ranking.

According to an article published in the Sports Medicine Journal, nitric oxide can people who are just beginning to exercise become more “tolerant” – or, less affected by the shock to the muscles, and more likely to continue with their new routine.

Another study published in Frontiers in Physiology found that nitric oxide can also manage the exaggerated blood pressure response that older people can experience when they do aerobic or resistance exercise.

These studies show that nitric oxide supplements can help anyone get more out of their exercise routine, whether you’re an elite athlete preparing for a competition or a senior who needs to manage your blood pressure during your workout.

If you’re looking to improve your performance, also make sure your body gets enough protein. You can look into adding a protein powder for muscle gain to your routine.

Reduce muscle soreness

Weight training can leave your muscles sore for days, affecting your performance or even desire to return to the gym the next day.

However, nitric oxide can reduce soreness or shorten its effect. By increasing the blood flow to the muscles, it clears the lactic acid and replenishes the tissues with nutrients and oxygen. It prevents extreme fatigue, muscle cramps, and the overall feeling of weakness.

Since you recover faster, you can return to the gym with full energy levels, and can give more (and get more) from every workout.

Top-Rated Nitric Oxide Booster Ingredients

Nitric oxide supplements don’t actually contain the substance itself, but are rich in compounds that your body uses to produce it. They usually contain one or more of the following ingredients.

Beet root powder

Beets are one of the best dietary sources of nitrates. While you can eat it fresh in a salad or a juice, not many people enjoy the earthy taste. Beet root powder is the concentrated form made from dried, ground beets—more convenient, and for many, more tolerable.

There is a lot of research that links beet root powder (or other forms like juice) with improved health and performance. One study that involved professional bicyclists found better racing time and endurance.

Other studies show that beet root powder supplements can lower systolic blood pressure. However, the results are temporary (up to six hours) so it’s important to take the supplement every day to enjoy its benefits.

As an antioxidant, beet root powder also has extra benefits for the skin and immune system. It can also fight inflammation, so it can help manage chronic inflammatory diseases like osteoarthritis.

There is an important side effect of high beet root powder intake, though: it can increase the possibility for kidney stones. If you have a history of this disease, it’s best to find a nitric oxide supplement made of another ingredient.


L-arginine is a kind of amino acid. Your body converts into nitric oxide and other substances that stimulate the release of insulin and growth hormones. That’s why it’s one of the best ingredients you can find in a nitric oxide supplement: you improve blood flow, control sugar, and increase muscle gains.

L-arginine has been effective for controlling high blood pressure and correcting peripheral arterial disease (or poor blood flow to the limbs). For people with very mild blood pressure problems, it may decrease the need to take prescription drugs—with the approval of the doctor, of course.

Studies also show that it can improve sexual function, especially when used with other medications like tadalafil, sildenafil, or yohimbine.

L-arginine can also help widen blood vessels for people who have angina. Regularly taking nitric oxide supplements will help them manage chest pains and other symptoms, and improve their ability to exercise and overall quality of life.


L-citrulline is an amino acid. The liver converts into l-arginine, which is used to produce nitric oxide. It is more “stable” than l-arginine, which can degrade when it passes through the stomach or gastro-intestinal tract or liver.

L-citrulline is also less likely to cause diarrhea or stomach upsets, so if you experience these symptoms while taking nitric oxide supplements consider looking for one that’s made from L-citrulline instead.

L-citrulline has been linked with improving athletic performance. One study of weight trainers found that participants who took a supplement everyday were able to do 53% more reps than those who just took a placebo, and felt less muscle soreness after their workout.

That’s why it’s also included in some of the best pre workout supplements on the market.

L-citrulline’s effect on ED has not been as studied as much as that of l-arginine. However, the initial research is quite promising: studies show nearly 10% improvement in ED scores, especially when combined with other prescription drugs under the doctor’s supervision.

Like other nitric oxide supplement boosters, L-citrulline is quite effective for improving blood flow and blood pressure. There is also research being done on its mood-boosting benefits, particularly in managing mild depression.


L-Norvaline is a common ingredient in nitric oxide supplements and other pre-workout supplements. It helps preserve arginine in the body, so there’s more blood flow to the muscles. It’s associated with higher energy levels during your workout and faster recovery time.

A few years ago, people became wary of using L-Norvaline because of reports that it could damage brain cells and increase risk for neuro-degenerative diseases like Alzheimer’s. However, this has been debunked by other research.

Several scientists have questioned the controversial study, saying that the risks have been overstated. The cell damage only occurred in rats after being exposed to very toxic levels of L-Norvaline—several hundred times more than what a person would ingest from taking supplements.

The proven benefits also outweigh any imaginary, exaggerated risks. L-Norvaline is popular in the body-building community because the improved blood flow (and energy levels) can help with the power lifts and endurance.

L-Norvaline also helps prevent the inflammation often caused by strength training, especially for those who are just starting to lift heavy weights. Improved blood flow lessens the inflammation and help it subside faster, so recovery is less painful.

Vaso 6

Vaso 6 is one of the newest ingredients used in nitric oxide supplements. It is made from grapeseed and green tea extracts, which contain compounds called catechins. These help blood vessels dilate while providing all the other benefits of natural antioxidants, such as being an anti-inflammatory and anti-oxidant.

However, Vaso 6 is not just a simple green tea extract similar those you find in skincare or homeopathic remedies. Those pure extracts are a mixture of polyphenols and catechins.

Vaso 6 only uses specific compounds in grapeseed and green tea that can relax blood vessels. Their effectiveness is heightened by the addition of gallic acid. So, they are very different from the extracts you’d find in other products

Clinical trials of this revolutionary ingredient show that a 300mg dose can increase blood vessel dilation by as much as 50%. That’s a massive improvement in blood flow, which can boost both your workout and reduce the strain on your heart.

Vaso 6 is primarily marketed as an exercise supplement, so there is not much independent clinical research on its effectivity for lowering blood pressure or addressing erective dysfunction. If you’re primarily getting a nitric oxide supplement to improve muscle gains, then this is a good choice. If you need several benefits, then you may be better off with L-arginine or L-citrulline.

How We Chose The Best Nitric Oxide Supplements

There are hundreds of supplements that make the same claims—why did we pick the ones on our list? Our choice was based on strict criteria and frequently asked questions on forums.

We asked ourselves, “What do people look for? What would make it easier for them to decide what’s right for them?”

Ingredient list

Many so-called superfoods or mega-nutrients are simply trends that fizzle out after a few months. They have no real scientific basis, so you’re not sure what results you’re going to get.

That’s why one of the most important criteria was the efficacy of the ingredients. We looked at studies published in credible scientific or medical journals, and checked if the company had done any tests on their product.

We also checked the quantity of the ingredient, and how it is delivered to the body. How much of the active ingredient is in the formula? Is it extracted in a way that preserves the nutrients and make it easier for the body to absorb?

All these help ensure that the supplement can give real results, and you’re not being hoodwinked into buying a placebo.


Aside from extensive research, we also tried the product ourselves to see if it lived up to its claim. After all, the proof is in the pudding—and we wanted to see not just its impact, but how we felt while taking it. This includes side effects, or whether it was convenient to take.

We also considered that people will have different needs, concerns and fitness levels while looking for a nitric oxide supplement. Some will want the power boost to get through a hard workout; others are more interested in controlling blood pressure.

That’s why our list includes supplements for different kinds of users, and mentions alternatives for those who have specific health risks or sensitivities (such as a tendency to get stomach upsets, or low fitness levels).


We scoured reviews to find out if customers had any complaints about the products or the customer service.

After all, even if a product looks good on paper, we had to make sure that the entire purchase experience was pleasant. For example:

  • Did people get the goods on time?
  • Was it easy to contact the brand for returns if there was a problem?
  • How does it compare to other supplements they’ve tried?


We tried to include supplements with different prices, from premium products that are considered best in class, to affordable alternatives for people on a budget.

But more than the price tag, we also looked at value for money. No matter how cheap a product is, if it doesn’t contain effective ingredients, you are ultimately throwing your cash away.

So, we compared cost to actual results, so you never overpay for a product that doesn’t deliver on its claims.

Should You Use A Nitric Oxide Supplement?

A nitric supplement is worth taking if you have the following concerns:

  • You want to improve performance with a pre-workout supplement
  • You have high blood pressure, or at risk for high-blood pressure and heart disease
  • You are suffering from ED, and want a natural supplement that will complement your prescription medication
  • You have poor circulation issues, and experience numbing or tingling in your limbs
  • You have low energy levels

Do nitric oxide supplements have side effects?

Nitric oxide supplements are generally safe to use. You may experience minor symptoms as your body adjusts to it, such as diarrhea or lightheadedness, but these will go away after a few days.

However, everyone has certain sensitivities, and our review will indicate alternatives if you realize a product doesn’t agree with you.

However, even the safest supplements can cause problems if you use them incorrectly. Always follow the manufacturer’s instructions for dosage, and consult a doctor if you have a medical condition or are using prescription medication.

The bottom line

When you improve blood flow, you give your body the oxygen and nutrients it needs to be at its best.

Nitric oxide supplements are a safe way to achieve that—and with our list of the best ones available, you can pick the right one based on your needs and budget.