FOXBOROUGH, Mass. — Patriots linebacker Jerod Mayo, whose 546 tackles since 2010 are the most in the NFL, was placed on season-ending injured reserve Wednesday. After making a tackle Sunday, Mayo reached for the upper right area of his chest. But the team didn't disclose details of the injury, and his agent did not respond to a Yahoo report that Mayo had surgery for a torn chest muscle. Rookie Jamie Collins and fourth-year player Dane Fletcher are expected to fill in for Mayo.Meanwhile, receiver Danny Amendola (concussion) and corner Aqib Talib (hip flexor) missed practice. Their status hasn't been determined."We've lost some guys, dealt with some issues like every other team," New England quarterback Tom Brady said "We're handling them okay. We're 5-1. It's a decent start." Manuel out: Bills quarterback EJ Manuel will miss another 4-6 weeks with a sprained right knee. The former Florida State star was hurt Oct. 3. The team said then his return wouldn't be known until after swelling went done and doctors re-examined the knee. Giants sign Hillis: The Giants signed running back Peyton Hillis, whom the Bucs cut Sept. 21. Cowboys: Defensive tackle Jay Ratliff, an All-Pro in 2009 elected to the Pro Bowl in four consecutive seasons, was released after failing a physical. He had been on the physically unable to perform list after offseason surgery for a sports hernia and a hamstring injury sustained just before training camp. Jaguars: Receiver Justin Blackmon missed practice with a tight groin and hamstring. His status hasn't been determined. Jets: Corner Dee Milliner practiced on a limited basis for the first time since hurting a hamstring Sept. 25. His status hasn't been determined. Lions: Defensive tackle Ndamukong Suh was fined $31,500 for Sunday's late hit on Browns quarterback Brandon Weeden, the Associated Press reported. Rams: Right tackle Rodger Saffold practiced for the first time since hurting his left knee during the opener. His status hasn't been determined. Ravens: Linebacker Jameel McClain practiced for the first time since sustaining a spinal cord contusion Dec. 9. He will remain on the physically unable to perform list for at least this week. Steelers: Linebacker Jarvis Jones missed practice with what the team called a "head injury." Texans: Quarterback Matt Schaub missed practice with the ankle injury sustained Sunday. T.J. Yates and Case Keenum split first-team reps. Also, starting safety Danieal Manning is out for the season with a right knee injury. The team didn't disclose details of the injury. Titans: Quarterback Jake Locker practiced for the first time since injuring his right knee and right hip Sept. 29 but is expected to sit Sunday.