Tonight: Colts at Texans
When/where: 8:25; NRG Stadium, Houston
TV/radio: Ch. 10, NFL Network; 1010-AM, 98.7-FM
Line/OU: Colts by 3; 46
Indianapolis has dominated the relatively weak AFC South, winning its last nine games in the division. The Colts' last division loss came in December 2012 at Houston. The Texans won't have the No. 1 overall pick as injured pass rusher Jadeveon Clowney probably won't take the field until Week 7. Houston's defense has been solid, but it is facing a Colts offense that's tied with the Eagles for the most points in the league.
MATT BAKER'S PICK: Colts 28-21