USF is a three-plus touchdown favorite at home against an East Carolina team that stunned North Carolina.
Florida is a 4.5-point favorite at a Tennessee team playing its SEC opener under first-year coach Jeremy Pruitt.
And Florida State is a 10.5-point favorite at home against a Northern Illinois team it paid $1.6 million to come to Tallahassee.
Here’s our picks for those and other top games from week 4 in college football (! indicates lock of the week; * indicates upset special):