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College football picks for week 4: Times staff predictions

Here’s the Tampa Bay Times college football coverage team’s picks for week 4
 
South Florida Bulls student section during the game against Georgia Tech at Raymond James Stadium in Tampa, Florida on Saturday, September 8, 2018.  OCTAVIO JONES   |   Times
South Florida Bulls student section during the game against Georgia Tech at Raymond James Stadium in Tampa, Florida on Saturday, September 8, 2018. OCTAVIO JONES | Times [ JONES, OCTAVIO | Tampa Bay Times ]
Published Sept. 21, 2018|Updated Aug. 16, 2022

USF is a three-plus touchdown favorite at home against an East Carolina team that stunned North Carolina.

Florida is a 4.5-point favorite at a Tennessee team playing its SEC opener under first-year coach Jeremy Pruitt.

And Florida State is a 10.5-point favorite at home against a Northern Illinois team it paid $1.6 million to come to Tallahassee.

Here’s our picks for those and other top games from week 4 in college football (! indicates lock of the week; * indicates upset special):